2026 / 01

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DOI: 10.24075/brsmu.2026.002
Copyright: © 2026 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Comparative proteomic and genetic testing methods in miscarriage

Klimenko PA1 , Lisitsa AV2 , Petushkova NA2 , Veiko NN3 , Kostyuk SV3 , Ershova ES3 , Klimenko MP1 , Gerasimova AA4 , Yusef OV1 , Vaschenko SI1 , Kurtser MA1
About authors

1 Pirogov Russian National Research Medical University, Moscow, Russia

2 Institute of Biomedical Chemistry, Moscow, Russia

3 Institute of Biology of Aging and Healthy Longevity Medicine with a Clinic of Preventive Medicine, Petrovsky National Research Centre of Surgery, Moscow, Russia

4 Peoples' Friendship University of Russia, Moscow, Russia

Correspondence should be addressed: Pyotr A. Klimenko
Novatorov, 3, Moscow Москва, 119421, Russia; ur.umsr@ap_oknemilk

About paper

Funding: the study was conducted as part of the Program for Basic Research in the Russian Federation for the Long Term (2021–2030) (No. 122030100170-5).

Acknowledgements: mass spectrometry measurements were conducted using the equipment of the Human Proteome SRF of the Institute of Biomedical Chemistry (Russia).

Author contribution: equally.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Pirogov Russian National Research Medical University (protocol No. 228 dated 17 April 2023). All the surveyed individuals submitted the informed consent to take part in the study.

Received: 2025-12-08 Accepted: 2026-01-19 Published online: 2026-01-28
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Fig. rDNA copy number in DNA isolated from three types of cells in groups I–III. А. The mean copy number in the DNA sample (n = 3) and the measurement error are provided. B. Alteration of rDNA copy number in embryonic and decidual tissues relative to rDNA levels in blood leukocytes
Table 1. Pregnancy-specific glycoproteins (PSG) detected in human chorionic villi by panoramic mass spectrometry (LC-MS/MS)
Note: NSAF — normalized spectral abundance factor reflecting protein content.
Table 2. Descriptive statistics for R parameter
Note: the data are presented as the median (min–max); descriptive statistics for quantitative variables are presented as the mean and standard deviation — M (SD); sample C — blood from the patient’s cubital vein; sample E — embryonic tissue; sample D — decidual tissue.