Author contribution: Kerimov KB — study design, experimental procedure, calculations; Ivanov AS — study design, experimental design; Tananakina TP — study design, experimental design, scientific supervision; Kashchenko SA — scientific editing, scientific supervision, part in preparing the experiment; Pogorelova IA — technical proofreading, part in preparing the experiment.

Compliance with ethical standards: the study approved by the Ethics Committee of the St. Luke Lugansk State Medical University (protocol No. 2 dated May 26, 2026) was fully compliant with the Eurasian Economic Commission (EEC) Board "Guidelines for the Use of Laboratory (Experimental) Animals in Preclinical (Non-Clinical) Studies" dated November 14, 2023, No. 33, principles of the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes, as well as the Directive of the European Parliament and of the Council of the European Union on the Protection of Animals Used for Scientific Purposes. All the patients submitted the written informed consent for the material collected to be used for experimental purposes.