Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

Bulletin of RSMU

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

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Lyadova MV, Tuchik ES, Lyadova AV

The article is devoted to the problem of trauma doctors' legal awareness of emergency medical assistance. Based on the results of sociological investigations, there were demonstrated the main causes of conflicts between doctors and patients and the ways to prevent them.

Received: 2015-02-17

Published online: 2017-01-05

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VIEWS 3582

Komissarova OG, Konyaeva OO, Berezhnaya OO, Abdullaev RYu, Vasilyeva IA

The aim of the study was the comparison of the characteristics of clinical manifestations and efficacy of treatment of patients with pulmonary tuberculosis with multiple and extensively drug-resistant M. tuberculosis combined with different types of diabetes mellitus. There were studied 41 patients with pulmonary tuberculosis combined with diabetes mellitus type 1 and 30 patients with pulmonary tuberculosis combined with diabetes mellitus type 2. It was established that patients with diabetes mellitus type 1 often diagnosed infiltrative pulmonary tuberculosis, while in patients with diabetes mellitus type 2 it was often found fibrous-cavernous pulmonary tuberculosis. Efficiency of complex treatment for bacterial excretion extinction in the two groups was not significantly different (73.2 and 66.7 %, respectively). However, the treatment for closing of cavities in the lung was more effective in patients with diabetes mellitus type 1 (accordingly 61.0 and 36.6 %), which was probably due to the peculiarities of tuberculosis process in those patients.

Received: 2015-02-03

Published online: 2017-01-05

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VIEWS 3785

Radtsig EYu, Zlobina NV, Lapitskaya AS, Selkova EP

The article presents data on the etiology of acute adenoids against ARVI in children based on the results of microbiological (bacteriological, virological, mycological) study. Frequency of occurrence of various viral and bacterial pathogens is presented.

Received: 2015-04-07

Published online: 2017-01-05

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VIEWS 3494

Kotova EN, Bogomilsky MR

The article presents the literature and own data on the diagnosis and methods of surgical intervention for congenital choanal atresia in children. It is described, the method of endoscopic transnasal choanotomy, applied by the authors. A new variant of the stent used for the formation of choanal stoma in the postoperative period with the aim of increasing the effectiveness of surgical intervention and prevention of restenozation is suggested.

Received: 2015-04-07

Published online: 2017-01-05

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VIEWS 3871

Gamidov SI, Polivoda MD, Krasova OM, Popova AYu, Dubova EA, Pavlov KA

The aim of the study was to estimate the effect of the level and duration of the obstruction of the seminal tract on the morphological and functional state of the testicular tissue. 50 adult outbreed male laboratory rats were observed in the study. The rats were divided into 4 groups: 1 — vas deferens obstruction proximally, 2 — vas deferens obstruction distally, 3 — epididymis obstruction, 4 — controls (intact animals). The testes and epididymis were removed in 3 and 6 months for histological examination. Testicular volume and spermatogenesis status decreased in all groups. Also, these changes depend on the level and duration of the obstruction of the seminal tract.

Received: 2015-02-04

Published online: 2017-01-05

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VIEWS 3640

Anosov AK, Belakina NS

Therapeutically important cyclooxygenase-mediated unsaturated fatty acids oxidation stimulation in the isolated rabbit leukocytes during and after UV irradiation in the absence of Ca2+ in the incubation media was studied. It was shown that (1) photoinduced activation of the cyclooxygenase-dependent unsaturated fatty acids oxidation in the rabbit leukocytes is maximal after irradiation of the cells by UVC radiation in the dose 1,28 x 102 einstein/m2 with following incubation during 60 min at 37 °C; (2) photoinduced activation of the cyclooxygenase-dependent unsaturated fatty acids oxidation in the rabbit leukocytes is accompanied by inhibition of these cells chemiluminescence responses to forbol-12-miristate-13-acetate stimulation.

Received: 2015-11-11

Published online: 2017-01-05

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VIEWS 3681

Egorov ES, Israelson MA, Kasatskaya SA, Chudakov DM, Lukyanov SA

Over the past few years the High Throughput Sequencing technologies have become well established in modern biology and medicine. Fundamentally new opportunities for genome sequencing and in-depth analysis of various DNA and RNA libraries have been discovered. However, new technologies come with new pitfalls such as limitations in obtaining valid qualitative and quantitative data in the in-depth analysis of complex libraries. A clear understanding of these limitations is necessary for the accurate interpretation of the collected data as well as for the search for technological solutions to minimize their impact. The following review shows how molecular barcoding helps normalize samples efficiently and eliminate PCR and sequencing errors while preserving the actual diversity of libraries in the course of HTS analysis of complex libraries.

Received: 2015-09-28

Published online: 2017-01-05

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VIEWS 4329

Shibaeva AV, Aymadinova NK, Trubnikova EV, Kuznetsova TV, Zorina OA, Kudykina YK, Shevelev AB

In a real-time polymerase chain reaction-based assay with a Dentoflor kit Prevotella intermedia, a periodontal pathogen, was found to be present in 55 % of patients with chronic periodontitis. This percantage is significantly lower than the corresponding statistic for Porphyromonas gingivalis, Tannerella forsuthensis and Treponema denticola. In addition, hypercolonization of periodontium by P. intermedia was detected in 7.7 % of patients in the control group. This suggests that P. intermedia hypercolonization is an important prognostic factor indicating the severity of periodontal disease. The abnormal increase in P. intermedia is rarely a result of a monoinfection. Compared to other “red complex” pathogens, this species is more likely to co-occur with P. gingivalis, T. forsythensis and T. denticola, which leads to the most severe forms of chronic periodontitis. Unlike other “red complex” pathogens, P. intermedia showed no significant difference in occurrence and the degree of periodontal damage in male and female individuals with equal colonization levels.

Received: 2015-09-13

Published online: 2017-01-05

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VIEWS 4244