Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

Bulletin of RSMU

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

Scopus

SCImago Journal & Country Rank

Log In Registration RU

Khashukoeva AZ, Svitich OA, Markova EA, Khlynova SA, Narimanova MR, Sukhova TN

The aim of the investigation was the analysis of TNFα gene expression in blood mononuclear cells and the production of cytokines (TNFα, IFN-α, TGF-β1) in the serum of patients with herpesvirus infection (HVI) and recurrent pregnancy loss (RPL) in their anamnesis, who underwent blood photomodification sensitized by photodithazine. There were examined and treated 74 patients with herpesvirus infection without recurrent pregnancy loss (group 1 — 36 women), and with recurrent pregnancy loss in their anamnesis (group 2 — 38 women). There was evaluated TNFα gene expression and the cytokine profile before the treatment, during and after the therapy. Patients in group 1 revealed a significant reduction of the dynamics of TNFα gene expression during the therapy, and in 60 % of the women there was marked the decrease of TNFα production. In group 2 the reliable reduction of the dynamics of TNFα gene expression and decreased production of TNFα in 10 days from the start of the treatment was detected in 62.5 % of patients. There was established a significant increase of the TGF-β1 level in patients of group 1 during the therapy. In group 2 there was revealed a mediated increase of TGF-β1 by the end of the treatment (the 18th–20th days), which is positive and contributes to the inhibition of the replication of herpes simplex virus. The results obtained indicate a positive effect of photosensitized modification of blood in patients with the relapsed HVI on the background of the RPL.

Received: 2014-10-07

Published online: 2017-01-05

DOI:

Comments 0

VIEWS 3848

Makarov OV, Kozlov PV, Kuznetsov PA, Kopylova YuV, Vinokurova IN, Dzhokhadze LS, Osmanova AP

Vascular growth factors play an important role in the formation and functioning of the fetoplacental complex. The paper analyzed angiogenic status in patients with placental insufficiency with intrauterine growth restriction and preeclampsia. In all pregnant women there was investigated serum level of PIGF, sFlt-1 and sEng at 28–34 weeks of gestation by the method of enzyme-linked immunosorbent assay. Preeclampsia and intrauterine growth restriction are characterized by a decrease in pro-angiogenic growth factors on the background of increasing concentrations of anti-angiogenic agents.

Received: 2014-10-07

Published online: 2017-01-05

DOI:

Comments 0

VIEWS 3980

Kozlov PV, Bogaeva II, Ivannikov NYu, Kuznetsov PA, Dzhokhadze LS

Until now strategy of management of incomplete pregnancy with registered absent end diastolic flow (AEDF) in the umbilical artery in the preterm has not been worked out. There were analyzed 29 cases of singleton pregnancy, when AEDF in the umbilical artery was registered at 25–37 weeks of gestation. It was established that in preterm pregnancy and registration of AEDF in the umbilical artery prolongation of pregnancy in order to prevent the development of respiratory distress syndrome of the fetus is possible if cardiomonitoring observation reveals normal heart rate variability, reactive non-stress test and/or normal respiratory movements and normal volume of amniotic fluid. After 34 weeks of gestation with registration of AEDF in the umbilical artery, pregnancy prolongation is inappropriate.

Received: 2014-10-07

Published online: 2017-01-05

DOI:

Comments 0

VIEWS 3931

Kuznetsov PA, Kozlov PV, Dzhokhadze LS, Konstantinova KI

Non-immune fetal hydrops is a heterogeneous disorder, which is the final stage of the development of different antenatal diseases of the fetus. Contrary to popular belief, the infection is not the main cause of this disease. This article describes the unique case of non-immune hydrops of one fetus from the twins.

Received: 2014-10-07

Published online: 2017-01-05

DOI:

Comments 0

VIEWS 3653

Miroshnichenko IV, Stolpnikova VN, Levashova TV, Sorokina EA, Toporova SG

The aim of the study was to determine the markers and the stages of the immunosenescence. The data of flowing polychrome cytometry of 155 patients at the age of 80–89 years (group 1) and 276 patients at the age of 90–104 years (group 2) were analyzed. Immunograms were picked with homogeneous quantitative changes helper CD4+, cytotoxic CD8+ and activated CD3+HLA-DR+ T-cells. The average absolute values of indices with the analogous type of deviations from the standard did not depend on the age. However in the 2nd group persons with immunodeficiency were identified more often (80 ± 5 %) and less with activation of immunity (20 ± 5 %), than in the 1st group (33.5 ± 7.5 % and 66.5 ± 7.5 %, accordingly). It was assumed that the change of types of deviations from the standard reflects the sequential stages of natural immunosenescence, associated with quantitative CD4+ and/or CD8+ deficiency. Possibly the immune inflammation stimulates the accelerated aging against this background.

Received: 2014-05-30

Published online: 2017-01-05

DOI:

Comments 0

VIEWS 4028

Arshanskaya EG, Semochkin SV, Sotnikov VM, Ivanova VL

This article presents the analysis of long-term results of therapy of adolescents (n = 48; median age — 16.6 years; minimum and maximum age — 15.0 and 18.1) and young adults (n = 49; median age — 21.0 years; minimum and maximum age — 18.5 and 33.6) with primary Hodgkin's lymphoma (HL). During 1997–2008 all the patients were treated according to the pediatric protocol DAL-HD-90. Twelve-year event-free survival was 73.4 ± 4.8 % and overall survival — 81.5 ± 4.7 % for all patients. Twelve-year event-free survival for adolescents at the early stages of HL was documented at the level of 83.3 ± 15.2 %, at the intermediate stages — 80.9 ± 10.0 % and at the advanced stages — 72.2 ± 9.8 %. Long-term treatment results of young adults with intermediate and advanced stages of HL were inferior to those of adolescents. The frequency of secondary tumors in all patients was in 2.1 % of cases.

Received: 2014-06-24

Published online: 2017-01-05

DOI:

Comments 0

VIEWS 3920

Beloglazov VA, Popenko YoU

The aim of our investigation was to determine the state of anti-endotoxin (AET) immunity in patients with moderate and severe persistent bronchial asthma. 109 patients were examined receiving outpatient treatment of the basic disease. All patients were divided into two groups: group 1 — patients with moderate bronchial asthma — 68 subjects (62,4%) with average score of 3.00 ±0.14 according to ACQ, FEV<sub>1</sub> — 67.01 ± 2.10 %; group 2 — patients with severe bronchial asthma — 41 subjects (37,6 %) with average score of 4.06 ± 0.12 according to ACQ, FEV<sub>1</sub> — 34.45 ± 1.05 %. It was proved that in both clinical groups the levels of total secretory IgA and secretory AET-lgA in induced sputum were higher than those of healthy donors. It was observed the increase of the level of AET-IgM in blood serum in both clinical groups in comparison with donors, as for the level of serum AET-IgG patients of the studied groups were treated as normal responders. It was registered the increased level of AET-lgA in blood serum in group 1, in group 2 this indicator was getting closer to that of the donors. The increased level of C-reactive protein was determined in both groups. It is assumed that the imbalance of anti-endotoxin immunity influences the severity and the course of bronchial asthma according to the phenomenon of endotoxin aggression.

Received: 2014-06-06

Published online: 2017-01-05

DOI:

Comments 0

VIEWS 3868

Agapov MA, Gorskiy VA, Petrov VA, Polivoda MD, Kravchenko AYu, Battaev AI

The study of pathogenesis of acute pancreatitis and exploration of new treatment strategies are among the main scientific directions of urgent surgery. In connection with this, experimental models of acute pancreatitis are still an important research tool. In this review the invasive and noninvasive models of acute pancreatitis are presented. There are discussed disadvantages and positive features of each model.

Received: 2016-04-04

Published online: 2017-01-05

DOI:

Comments 0

VIEWS 3896