Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

Bulletin of RSMU

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

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Nasyrova NI, Ozolinya LA, Borisova MS, Askerova NG

The article presents a review of literature on the use of the «Da Vinci» surgical robot when conducting gynecological and oncogynecological surgeries. The experience of a few authorial collectives which have analyzed the use of robot assisted surgeries concerning the endometrial cancer, cervical cancer, hysteromyoma and the tubal pathology is discussed and compared to the similar surgeries performed without a robot by a laparoscopic or laparotomic access. The results of the comparative analysis have shown that the use of the robotics significantly improves the quality of the surgery and there is a decrease in loss of blood, pain syndrome during the postsurgical period as well as the time spent in the in-patient department. On the other hand, without proper experience the duration of the surgery becomes longer and the cost of the surgery goes up, considering the high cost of the materials used. However, as noted by the authors, after fifty successfully performed operations conducted by the robot their duration reduces and becomes comparable with the traditional operations, and the cost of the materials used is going to go down in the near future. That is why this method of surgical treatment in gynaecology considered as a progressive and perspective one.

Received: 2014-01-20

Published online: 2017-01-05

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VIEWS 3959

Makarov OV, Morozova KV, Goncharova VS, Lutsenko NN

Miscarriage still occupies a leading place among the main problems of medicine. In recent decades, special attention is paid to the system of genetic predictors of miscarriage. Special ferments are responsible for catecholamines exchange in the body, one of which is the catechol-o-methyltransferase, functional activity of which is genetically determined. DNA excision reparation system with the participation of the enzyme 8-oxoguanine-DNA glycosylase maintains the original structure of DNA, which is very important for the homeostasis of the organism. In our study we conducted genotyping of 274 patients for the presence of polymorphism of rs4680 gene COMT and polymorphism of rs1052133 gene OGG1 and determined their impact on the course of pregnancy. It was found that carriage of A/A and G/A rs4680 genotypes of COMT gene and G/G and C/G rs1052133 genotypes of OGG1 gene was associated with an increased risk of miscarriage.

Received: 2014-01-15

Published online: 2017-01-05

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VIEWS 3948

Novikova VA, Chernobay EG, Autleva SA, Aseeva EV, Torosyan KE, Kamenskikh GV, Glebova EV

At 35.6 ± 1.12 weeks of gestation there was performed the preinduction of labor with premature rupture of membranes (PROM) in 50 women. It was performed using an analogue of prostaglandin E2. Preinduction of labor efficiency for initiation of delivery in the absence of significant deterioration in perinatal outcomes was achieved in 84 % of cases. There were identified objective ways to evaluate the dynamics of the transformation of the cervix by ultrasound monitoring, depending on the method of preinduction of labor in women with preterm pregnancy and PROM. There was performed the analysis of features of utero-fetus-placental hemodynamics, uterine activity during preinduction of labor in women with PROM at 34–36 weeks gestation.

Received: 2014-01-14

Published online: 2017-01-05

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VIEWS 4003

Runikhin AYu, Poryadin GV, Savchuk VI

The aim of the study was the evaluation of prostaglandin E2 (PGE2) influence on cholinergic cardiac innervation. Our experimental investigation established that PGE2 induced cardiodepressor effect in normotensive cats (n = 88) due to vagus nerves activation. PGE2 stimulated vagal C-afferent fibers thus leading to vagotonia. Vagotonic effect of PGE2 is one of the mechanisms for myocardium contractility and antihypertensive action. PGE2 modulating cholinergic influence may improve blood pressure control and morphology and function of vital organs.

Received: 2013-09-02

Published online: 2017-01-05

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VIEWS 3951

Zaiko MV, Teselkin YuO, Pavlova LA, Kozin SV

In the study the ability of dihydroquercetin to inhibit the development of free radical reactions in the process of storing a new animal extracted product «Splenaktiv» (SA), which is a freeze-dried aqueous extract of the cattle spleen, was investigated. SA was prepared without (SA-1) and with dihydroquercetin supplement as an antioxidant (SA-2). The antioxidant activity of SA-1 and SA-2 and the content of lipid peroxidation product — malondialdehyde — were determined before and after storage for 2 years. It was found that after the period of storage of the selected antioxidant activity of the animal extracted product SA-1 decreased by10 times, and the content of malondialdehyde increased by 2 times as compared to baseline (p <0.01), whereas in the case of SA-2 the appropriate parameters practically did not change. Thus, the use of dihydroquercetin as an antioxidant in the composition of SA inhibits the development of oxidation processes and increases its shelf-life.

Received: 2014-01-27

Published online: 2017-01-05

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VIEWS 3958

Melentyev IA, Vershinin AA, Melentyev AS, Malygina NA, Kostomarova IV

Depending on the insertion-deletion polymorphism of the angiotensin-converting enzyme and Hindlll DNA polymorphism of lipoprotein lipase gene there were studied the clinical course of coronary heart disease and five-year survival of patients after an exacerbation of the disease. It was found that the most important genetic predictors of short- and long-term adverse outcomes of acute ischemic heart disease are the genotype H+H+ of lipoprotein lipase gene, DD genotype of the angiotensin-converting enzyme gene and the combination of these genotypes.

Received: 2014-05-26

Published online: 2017-01-05

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VIEWS 4419

Badamshina GG, Karimova LK, Timasheva GV, Bakirov AB

A complex clinical-hygienic study in employees of a petrochemical complex for the production of synthetic resins was conducted. The main hazardous factor in the working environment under the study was a chemical production factor which was represented by 2–3 class hazards. In general, the working conditions were closely matched to class 3.3 according to the level of a chemical factor. The priority classes of chronic non-infectious diseases among petrochemical workers revealed statistical evidence for association of the disease with the work, characterizing the professional risk to the health of the workers.

Received: 2013-11-11

Published online: 2017-01-05

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VIEWS 3892

Gimranova GG, Bakirov AB, Karimova LK, Beygul NA, Shaykhlislamova ER

We have assessed occupational risks among oil extraction workers using hygienic and medico-biological criteria. In modern oil extraction enterprises, a complex of work environment and work process factors includes occupational noise, vibration, hazardous chemicals impact, outdoor air negative indicators, work severity and intensity. Working conditions in certain occupations are characterized by a combination of predominating factors. Their intensity is of class 3 (1-4 degree) hazards. The presence of hazardous factors leads to the development of occupational and work-related diseases among workers. The highest health occupational risk level is detected in drillers, assistant drillers, operators of major, underground drill hole repairs, and machine operators. Optimization measures for occupational risk management have been developed.

Received: 2013-11-11

Published online: 2017-01-05

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Comments 0

VIEWS 3794