Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

Basic principles of liquid chromatography-tandem mass spectrometry method (LC-MS/MS) and its role in drug discovery and preclinical studies are reviewed. Three stages and components of the method in modern bioanalysis application are considered — sample preparation, liquid chromatography and mass spectrometry. The method trends and features for early drug screening and subsequent preclinical study of pharmacokinetics of drugs are discussed.

Received: 2014-01-22

Published online: 2017-01-05

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Chekhani NR, Pavlova LA, Kozin SV, Teselkin YuO

The influence of natural polyphenolic compounds included in a new collection of medicinal plant products on the physical endurance of mice in the re-swim test was studied. It was found out that the course application of aqueous extract from the plant collection in the experimental group of mice did not effect the duration of the primary swim, but increased to 1,7 times the length of re-swimming against the same parameter in the control group (p <0.001). This result demonstrates the positive effect of the proposed plant collection on the recover processes after physical activity, i.e. its actoprotective action. It is assumed that the actoprotective action of the medicinal plant collection is due to antioxidant properties of biologically active substances in its composition.

Received: 2013-12-25

Published online: 2017-01-05

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Prokhorova OG, Nozhkina NV

The article presents the results of the study aimed at investigating the epidemiological features of HIV infection among women and children in the Sverdlovsk region and to assess the prevention, medical and social programs impact. The study was performed for the period of 1990–2012, epidemiological, sociological and statistical methods were used. By 2012 it was set a steady increase in the share of women in the HIV-infected. At the age under 29 the proportion of women among people living with HIV prevails over men. Sexual transmission of HIV among women reached 70.0 %, prevalence of pregnant women — 2.0 %. Due to inter-departmental prevention programs and integrated health and social care there was increased the level of chemoprophylaxis among pregnant women and mother-to-child transmission of HIV decreased to 3.9 %.

Received: 2013-11-11

Published online: 2017-01-05

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Karelin AO

The article represents the classification of information risk factors in the post-industrial society, comparative analysis of the distribution of mobile phones among students of Saint-Petersburg in 2002–2010. A questionnaire method was used. There was revealed unsatisfactory information among students about the risk factors of using mobile phones. Information risk factors are a challenge for the post-industrial society.

Received: 2013-11-11

Published online: 2017-01-05

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Denisov EI, Eremin AL

The increasing flow of information affects the human health and assumes active involvement of hygienists. The place of information hygiene in the preventive medicine is considered. Some physical and hygienic aspects of information measurement and assessment are discussed along with its negative effects. International and Russian regulatory documents in the field are mentioned. In connection with the strategy of innovative development of Russia hygienic aspects of the evaluation of innovations and prospects for the development of hygienic standards are analyzed.

Received: 2013-11-11

Published online: 2017-01-05

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Potapov AI, Rakitskiy VN, Tulakin AV, Lutsenko LA, Ilnitskaya AV, Egorova AM, Gvozdeva LL

The article analyzes the Russian and foreign experience, international standards, reports and recommendations, concerning the assessment of superfine aerosols and aerosol nanoparticles in the working area.

Received: 2013-11-11

Published online: 2017-01-05

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Valeeva ET, Bakirov AB, Karimova LK

The present paper summarizes long term studies on the assessment of working conditions and chemical workers' health. The enormous factual material allowed to estimate occupational risks for workers' health and to rank hazardous chemical manufactures by their degree of risk, to develop preventive measures.

Received: 2013-11-11

Published online: 2017-01-05

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Roslaya NA, Plotko EG, Lebedeva AV

The aim of the study was to evaluate the influence of occupational risk factors on the health status of healthcare workers in the Sverdlovsk region. Complex hygienic assessment of the working conditions of healthcare personnel revealed a number of professional risk factors: physical, chemical, biological, as well as hardness and intensity of the work, which may have an unfavorable effect on the health. To the high risk group of occupational diseases relate surgeons as well as the nursing staff of surgical and therapeutic profile.

Received: 2013-11-11

Published online: 2017-01-05

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