Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

Bulletin of RSMU

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

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Larina VN, Bart BYa, Golovko MG, Dergunova EN, Mamtsev BN

The aim of this study was to identify the factors negatively affecting the course of chronic heart failure (CHF) and prognosis in elderly patients having been observed in the polyclinic. Data were collected on 248 patients aged 60 to 85 years with CHF II–IV FC NYHA due to ischemic heart disease or hypertension. During the period over two years there were hospitalized 191 (77 %) patients. There were detected independent risk factors for hospitalization of elderly patients with heart failure and low adherence to treatment, as well as predictors of their development. It was shown that low therapy adherence was associated with non-severe chronic heart failure, preserved left ventricular ejection fraction and low level of a patient's education.

Received: 2012-07-02

Published online: 2017-01-05

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VIEWS 3123

Bart BYa, Zakharenko GD, Kasatikova LA, Kudina EV

The article is devoted to the history of the Department of outpatient therapy No. 1 of the Medical Faculty. It reflects the progress in the implementation of the Department's own methods of teaching in skills training, in the improvement of diagnostic methods and treatment of the diseases of the cardiovascular and bronchopulmonary systems in the prehospital period. There are outlined the main trends of educational-methodical and scientific research work.

Received: 2012-07-02

Published online: 2017-01-05

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VIEWS 3225

Tsitsiashvili MSh, Gubaydullin RR, Bagdatyev VE, Yakubov TJ

In this research we analyzed the changes in intra-abdominal pressure in 38 patients with local (17 patients) and generalized peritonitis (21 patients). The study found significantly higher intra-abdominal pressure in patients with advanced peritonitis than in patients with local peritonitis. In 53 % of patients with local peritonitis intra-abdominal pressure was not observed, and 47 % of patients had its I degree. In the group of generalized peritonitis all patients had intra-abdominal hypertension: I degree was observed in 17.4 % of patients, II degree — in 65.2 %, III degree — in 8.7 % and IV degree — in 8.7 % of patients.

Received: 2012-06-05

Published online: 2017-01-05

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VIEWS 3202

Vlasov AP, Shibitov VA, Vasilyev VV, Anaskin SG, Vlasov PA, Potyanova IV

The research of laboratory and clinical effects of a new antihypoxant at an acute peritonitis with an accent on studying modifications of lipid metabolism, lipid peroxidation activity and phospholipase A2, some indicators of endogenous intoxication and hypoxia was held. There were analyzed the results of the treatment of 65 patients with acute peritonitis of an appendiceal genesis. The antihypoxant was included in the complex therapy of the patients of the basic group in the early postoperative period. Preparation application led to fast positive clinical and laboratory dynamics and improved the results of the treatment. The major effect of the antihypoxant was in the reduction of the severity of endogenous intoxication by rising detoxication abilities of an organism and decreasing of membrane destructive processes due to reduction of lipid peroxidation and the hypoxia phenomena.

Received: 2012-06-01

Published online: 2017-01-05

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VIEWS 3266

Nikolskaya IA, Kopetskiy IS, Dubovaya TK, Vygorko VF, Volkov AG

In the study there was worked out a set of measures aimed at preserving the vitality and regeneration of dental pulp in an experiment on rabbits. It is given a comparative analysis of the characteristics of therapeutic pads based on hydroxyapatite ultrahigh dispersion and calcium hydroxide and their use in combination with a physiotherapeutic method of treatment — ozone therapy. These procedures were directed on increasing the protection of the pulp from external influences and created conditions for the invertibility of inflammation and regeneration. These pilot studies allow the development of new measures aimed at preserving the vitality of the tooth pulp and to achieve sustainable results in the treatment of patients in clinical practice.

Received: 2012-04-17

Published online: 2017-01-05

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VIEWS 3168

Lukoyanova TV, Bulgakov VS, Razumova SN, Zaslavskaya MI

The aim of the study was to define effectiveness of treating patients with chronic generalized periodontitis with ethidronate sodium and roxythromycin based on clinic and laboratory indices. 32 patients with chronic generalized periodontitis of moderate severity in the acute stage were examined. It was conducted an index assessment of oral health — Green-Vermillion (1964) index of personal hygiene, C.Parma (1960) papillary-marginal-alveolar index, A.Russel (1956) periodontal index. It was determined the depth of periodontal pockets with probing techniques and checking the degree of tooth mobility. In 100 % of cases in periodontal pockets using polymerase chain reaction there were identified various combinations of periodontal pathogens, such as Prevotella intermedia, Tannerella forsythia, Treponema denticola, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis which play a significant role in the development of periodontitis. In patients with chronic generalized periodontitis after the combined treatment with ethidronic acid and roxithromycin there was observed the normalization of clinical and laboratory parameters. These data contribute to the implementation of rational antibiotic therapy tactics.

Received: 2012-03-02

Published online: 2017-01-05

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VIEWS 3034

Aminulla AA, Filatov VV, Karalkin AV

The aim of this study was to compare the level of accumulation of the radiopharmaceutical (RPH) within the eye after an anterior noninjection method of infusing the drug into the conjunctival cavity followed by an insonation of the eye with infrasound (infrasound phonophoresis) and after injecting it through irrigation system in the retrobulbar space. The work was done on 10 Chinchilla rabbits. The animals were divided into testing and comparison groups, 5 rabbits in each. In the testing group the radiopharmaceutical was infused by an infrasound phonophoresis method. In the comparison group the radiopharmaceutical was injected into retrobulbar space through irrigation system. The conducted research showed that with the infusion of medical preparations by the infrasound phonophoresis method the level of accumulation of the radiopharmaceutical inside the eye was 1.9 times higher than the content of the radiopharmaceutical introduced in the retrobulbar space through irrigation system.

Received: 2011-12-12

Published online: 2017-01-05

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VIEWS 3124

Volkova EV, Lysyuk EYu, Djokhadze LS, Makarov OV

The aim of our study was to examine changes in levels of vascular growth factors in pregnant women with chronic hypertension (CH). There was carried out a clinical analysis of pregnancy, childbirth, postpartum and postnatal outcomes in 69 pregnant women with CH and 49 women with physiological course of pregnancy. The levels of proangiogenic (PlGF) and antiangiogenic (sFlt-1, sEng) factors in the serum of 28–34 weeks' gestation were investigated in all pregnant women with immune-enzyme analysis. At pregnancy with the CH there was observed an increase in the concentration of antiangiogenic proteins sFlt-1 to 5573 ± 774 pg/ml (3299 ± 544 pg/ml in control, p < 0.05) and endoglin to 7.1 ± 0.8 ng/ml (control 5.4 ± 0.4 ng/ml, p < 0.05). At the same time there was a decrease of proangiogenic PlGF (155.8 ± 30.4 pg/ml vs 238.5 ± 66.1 pg/ml in controls, p < 0.05).

Received: 2012-03-27

Published online: 2017-01-05

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VIEWS 3050