Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

Bulletin of RSMU

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

Scopus

SCImago Journal & Country Rank

Log In Registration RU

Issue 4, 2026

Topic PRP for injuries

Contents Download
Issue 5, 2025

Topic Age-related alterations in the immune system

Contents Download
Issue 6, 2025

Topic Anxiety and depressive disorders

Contents Download
Issue 1, 2026

Topic Miscarriage

Contents Download
Issue 2, 2026

Topic Postmenopause

Contents Download
Issue 3, 2026

Topic Meckel's diverticulum

Contents Download

PUBLICATION FEES

New articles

Ivanov AS, Tananakina TP, Kashchenko SA, Pogorelova IA, Alexandrov IA

Changes in the ratio of the C-reactive protein (CRP) pentameric (anti-inflammatory) and (monomeric) isoforms during treatment of combined metabolic disorders with glucocorticoids are still poorly understood. The study aimed to assess plasma concentrations of CRP and its isoforms (pentameric and monomeric) in rats with obesity combined with arthrosis. The experiment involved 180 male Wistar rats (n = 180; 8–10 weeks, 200–250 g) randomized into five groups (n = 36). The first one represented the control; obesity and arthrosis were simulated in groups II–V. Groups I and II were administered 1.0 mL of saline; groups III–V were administered 1, 10, 100 ng/mL of dexamethasone daily for 10 days; concentrations of CRP and its isoforms (pentameric and monomeric) were assessed by ELISA on days 3, 5, and 10. Calculation was performed using the Statistica 10.0 software; the data were presented as M ± SD with 95% confidence intervals, with p < 0.05. The increase in CRP levels was reported in group (arthrosis + obesity): by 2.1% on day 3, 26.4% on day 5, 174.5% by day 10 (p < 0.001) relative to the control (group I). Dexamethasone 1 and 10 ng/mL reduced inflammation on day 3 (CRP levels decreased by 7.9% and 26.1%, respectively (p < 0.05)); CRP levels increased by 231.6% and 152.3% by day 10 (p < 0.001). The dose of 100 ng/mL reduced CRP levels by 9.5% on day 5, showing the increase by 149.0% on day 10; p < 0.001. In group II, the mCRP concentration increased by 287.1% by day 10, and in groups III, IV, and V it increased by 360.2%, 270.9%, and 280.6%, respectively (p < 0.001). The nCRP concentration decreased by day 10 in groups II and V (by 25.7% and 18.1%; p < 0.05). No deaths or adverse reactions were reported. Conclusions: dexamethasone 1 and 10 ng/mL reduces the CRP concentration throughout 3 days, and the dose of 100 ng/mL up to 5 days with the development of resistance and the increase in total and monomeric CRP levels on day 10.

Received: 2026-08-27

Published online: 2026-10-19

DOI: 10.24075/brsmu.2026.057

Comments 0

VIEWS 39

Yurchenko KS, Adamenko LS, Kovalenko VS, Budko AI, Gagloeva TD, Timaeva OI, Trashkov AP, Shestopalov AM

In earlier experimental studies in vitro the Newcastle disease virus strain NDV/Altai/pigeon/770/2011 demonstrated significant cytolytic properties against various tumor cell lines, including colorectal cancer cells. It also inhibited the growth of various types of tumors in xenograft and syngeneic tumor models. The aim of the present study was to evaluate of the antitumor activity of several forms of NDV-containing drug on experimental adenocarcinoma CT26 and to compare the therapeutic effect with the classical cytostatic agent. Male BALB/c mice were used as model animals. Two experiments were conducted. In the first, intravenous antitumor therapy was started 48 hours after subcutaneous injection of CT26 tumor cells; in the second, therapy was started when the tumor reached a size of 150–400 mm3. A single injections of virus-containing drugs were administered for five days to mice from the experimental groups in each experiment: the unpurified form of the virus-containing drug and two purified forms of the virus-containing drug with the addition of hydroxyethyl starch and glucose. The mice in the control group were untreated. The comparison mice group was injected with cyclophosamide intraperitoneally (twice). According to the oncological parameters, therapy with an unpurified form of a virus-containing drug based on NDV strain proved to be effective, and the therapeutic effect was comparable in all major parameters with the group of animals receiving standard cyclophosphamide therapy.

Received: 2026-08-27

Published online: 2026-10-18

DOI: 10.24075/brsmu.2026.058

Comments 0

VIEWS 129

Tkachenko VV, Vorobyeva PE, Mosnaya AI, Khachatryan KA, Chnavayan DV, Chikun SV, Zaynullina RF, Kirsanova PV, Moiseeva AD

Ureteral metastasis from prostate cancer is an exceedingly rare manifestation of disease progression and may mimic a primary tumor of the upper urinary tract. The limited number of reported cases underscores both the uniqueness of this localization and the substantial diagnostic challenges it presents. This report describes a clinical case of delayed metastatic ureteral lesion in a prostate cancer patient 13 years after radical prostatectomy. At primary diagnosis, the neoplasm in the ureter was regarded as urothelial carcinoma. Following surgical resection and immunohistochemical analysis, the tumor was confirmed to be a metastasis from prostate adenocarcinoma (PSA+, CK7–/CK20–). This case illustrates the diagnostic complexity of atypical prostate cancer progression and underscores the need for a comprehensive pathomorphological evaluation to confirm the diagnosis and guide subsequent treatment decisions.

Received: 2026-08-25

Published online: 2026-10-08

DOI: 10.24075/brsmu.2026.055

Comments 0

VIEWS 286

Shabunin AV, Bagatelia ZA, Karpov AA, Maer RYu, Gugnin AV, Vengerov VYu, Pilyus FG, Karapetyan VD

Cholelithiasis is a common surgical disorder creating a high burden of the healthcare system. The introduction of minimally invasive technologies justifies the shift towards hospital-replacing models, but the institutional aspects of their use in the metropolis are still poorly understood. The study aimed to assess the role of hospital-replacing technologies in organizing elective surgical care provision to patients with cholelithiasis based on the retrospective analysis data for the years 2016–2025. A retrospective observational study was conducted based on the aggregate data of the Moscow City Health Department. The dynamics and structure of elective cholecystectomy procedures, the development of the short-stay unit (SSU) network, length of hospital stay, and age distribution were analyzed. The number of laparoscopic cholecystectomy procedures increased by 48%, the number of open surgical interventions decreased by 93.4%. The SSU network expanded from 5 to 30 units, the share of surgery due to cholelithiasis performed at the SSU reached 40.2% relative to the year 2016. The SSU stay was associated with the 75.0% bed-day reduction (to one day) and the actual hospital stay reduction by more than 80.0% (to 16.2 ± 7.4 h) compared to the round-the-clock hospital (RCH). Age differences (the share of patients over the age of 70 was 13.3% in the SSU vs. 36.0% in the RCH) support selective routing of patients at lower risk to the SSU. Conclusions: SSU has become an important organizational instrument of elective surgery due cholelithiasis that has ensured a sharp patient treatment time reduction over the preceding 10 years.

Received: 2026-08-24

Published online: 2026-09-29

DOI: 10.24075/brsmu.2026.054

Comments 0

VIEWS 302

Submit Manuscript

Popular articles

Saadoon SJ, Atiyah AM, Ibrahim AH, Mostafa FM

Secondary hyperparathyroidism (SHPT) is a common and progressive complication of chronic kidney disease (CKD), often intensifying as patients reach dialysis. Although alfacalcidol and other active vitamin D analogs are often used, improper administration can raise the risk of hypercalcemia and hyperphosphatemia. This study aimed to assess, using clinical criteria indicated by guidelines, whether alfacalcidol should be prescribed to hemodialysis patients with SHPT. Records of 136 adult patients treated in An-Naseria hemodialysis units were reviewed and analyzed using SPSS (version 26). The appropriateness of prescribing alfacalcidol was evaluated in accordance with KDIGO 2017 guidelines, taking into account levels of phosphate, calcium, and parathyroid hormone (PTH). Patients were divided into groups based on whether their prescriptions were appropriate or possibly inappropriate. Patients were 55.1% male and had an average age of 51.42 ± 11.5years. The majority of patients exhibited biochemical values (phosphate: 79.4%, calcium: 74.3%, and PTH: 77.2% normal) within goal ranges. 72 patients (52.9%) were categorized as potentially inappropriate for alfacalcidol medication, whereas 64 patients (47%) were recognized as having appropriate indications based on criteria consistent with guidelines. The mean PTH levels of patients in the appropriate group were substantially higher (923.14 ± 379.59 pg/mL) than those in the inappropriate group (274.71 ± 179.69 pg/mL, р < 0.001). Age, sex, calcium, and phosphate levels did not significantly correlate with prescription appropriateness. This cohort may have a significant percentage of alfacalcidol prescriptions that may not follow current guidelines. The sensible use of vitamin D analogs in hemodialysis patients may be improved by better adherence to evidence-based guidelines and routine biochemical monitoring.

Received: 2026-04-13

Published online: 2026-05-30

DOI: 10.24075/brsmu.2026.025

Comments 0

VIEWS 1008

Darawsheh HM, Mellin RV, Akulinichev EA, Moiseev DA, Snezhko OV, Kopetskiy IS, Vasiliev YuL

Treatment of mandibular fractures remains a pressing issue in maxillofacial surgery. This paper presents a novel single-jaw splinting technique (RF patent No. 2735258) for the immobilization of bone fragments in fractures located within the dental arch. Mathematical modeling using the finite element method (FEM), based on computed tomography data from one volunteer, was performed to assess its biomechanical efficiency. A 3D model of the mandible with the fixation construct and an indenter (simulating occlusal load up to 50 N) was constructed. The modeling results showed that the relative movement between the fragments was approximately 25 µm, which is comparable with literature data for two-titanium-plate osteosynthesis. The maximum equivalent stress values in the metal splint reached 100 MPa, and in the splint these reached 3 MPa. The developed method ensures stable fixation without involvement of the maxilla. The analysis involved only a single model and no experimental validation; therefore, confirmation in further research is required. Nevertheless, the obtained data suggest that the method is promising as an alternative to existing immobilization techniques.

Received: 2026-03-03

Published online: 2026-04-23

DOI: 10.24075/brsmu.2026.015

Comments 0

VIEWS 971

Special Project Author's Work

Secrets of a quality research study and a good manuscript

At the end of 2015, Bulletin of RSMU saw an important change in its typographic design and content. We formulated new editorial policies and established strict ethical standards for submitted manuscripts in accordance with the guidelines of reputable international bodies. As a result, about a quarter of the submitted works have been rejected, the primary reason being the author trying to submit a previously published article. Sometimes authors believe that by making slight changes to the introduction, excluding a few people from the study, performing a new statistical analysis, and thus obtaining totally new results they will turn their old manuscript into a novel work. That is why we would like to talk about scientific integrity, honesty, plagiarism, and self-plagiarism in our special project “Author’s work”.

American physicist Richard P. Feynman, a Nobel laureate, was always very scrupulous about the quality of a research study. During his commencement address at the California Institute of Technology in 1974, he talked about scientific integrity and honesty and warned young researchers “not to fool” themselves. A must-read for anyone who believes he/she is a true scientist.

In 1918, Russian physiologist Ivan Pavlov, a Nobel laureate, delivered two lectures: on the mind in general and the Russian mind in particular; on those mind qualities that determine the success of a research work and on how these qualities are present in the Russian mind. Pavlov's thoughts are an effective vaccine against poor intellectual work.