2019 / 05

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DOI: 10.24075/brsmu.2019.065

ORIGINAL RESEARCH

Prothrombogenic polymorphic variants of hemostatic and folate metabolism genes In patients with aseptic cerebral venous thrombosis

Maksimova MYu, Dubovitskaya YuI, Krotenkova MV, Shabalina AA
About authors

Research Center of Neurology, Moscow, Russia

Correspondence should be addressed: Marina Yu. Maksimova
Volokolamskoye Shosse, 80, Moscow, 125367; ur.liam@avomixamncn

About paper

Funding: the study was performed as a part of the public assignment of the Research Center of Neurology.

Author contribution: Maksimova MYu — concept development and study arrangement, clinical and laboratory data analysis, statistical analysis, manuscript writing; Dubovitskaya YuI — clinical examination of patients, data aquisition and primary analysis of the results; Krotenkova MV — brain MRI, MR venography and neuroimaging diagnosis of cerebral venous sinus thrombosis; Shabalina AA — laboratory analysis of prothrombogenic polymorphic variants of hemostatic and folate metabolism genes.

Received: 2019-08-19 Accepted: 2019-10-06 Published online: 2019-10-16
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  1. Behrouzi R, Punter M. Diagnosis and management of cerebral venous thrombosis. Clin Med (Lond). 2018; 18 (1): 75–9. DOI: 10.7861/clinmedicine.18-1-75.
  2. Maali L, Khan S, Qeadan F, Ismail M, Ramaswamy D, Hedna VS. Cerebral venous thrombosis: continental disparities. Neurol Sci. 2017; 38 (11): 1963–8. PubMed PMID: 28808795. DOI: 10.1007/ s10072-017-3082-7.
  3. Lee DJ, Ahmadpour A, Binyamin T, Dahlin BC, Shahlaie K, Waldau B. Management and outcome of spontaneous cerebral venous sinus thrombosis in a 5-year consecutive single-institution cohort. J Neurointerv Surg. 2017; 9 (1): 34–8. DOI: 10.1136/ neurintsurg-2015-012237.
  4. Agrawal K, Burger K, Rothrock JF. Cerebral sinus thrombosis. Headache. 2016; 56 (8): 1380–9. DOI: 10.1111/head.12873.
  5. Capecchi M, Abbattista M, Martinelli I. Cerebral venous sinus thrombosis. J Thromb Haemost. 2018;16 (10):1918–31. DOI: 10.1111/jth.14210.
  6. Coutinho JM, Zuurbier SM, Aramideh M, Stam J. The incidence of cerebral venous thrombosis: a cross-sectional study. Stroke. 2012; 43 (12): 3375–7. PubMed PMID: 22996960. DOI: 10.1161/ STROKEAHA.112.671453.
  7. Janghorbani M, Zare M, Saadatnia M, Mousavi SA, Mojarrad M, Asgari E. Cerebral vein and dural sinus thrombosis in adults in Isfahan, Iran: frequency and seasonal variation. Acta Neurol Scand. 2008; 117 (2): 117–21. PubMed PMID: 18184347. DOI: 10.1111/j.1600-0404.2007.00915.x.
  8. Coutinho JM, Zuurbier SM, Stam J. Declining mortality in cerebral venous thrombosis: a systematic review. Stroke. 2014; 45 (5): 1338–41. DOI: 10.1161/STROKEAHA.113.004666.
  9. de Freitas GR, Bogousslavsky J. Risk factors of cerebral vein and sinus thrombosis. Front Neurol Neurosci. 2008; (23): 23–54.
  10. Kashkoush AI, Ma H, Agarwal N, Panczykowski D, Tonetti D, Weiner GM, et al. Cerebral venous sinus thrombosis in pregnancy and puerperium: A pooled, systematic review. J Clin Neurosci. 2017; (39): 9–15. DOI: 10.1016/j.jocn.2017.02.046.
  11. Bushnell C, McCullough LD, Awad IA, Chireau MV, Fedder WN, Furie KL, et al. Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014; 45 (5): 1545–88. DOI: 10.1161/01.str.0000442009.06663.48.
  12. Ilyas A, Chen CJ, Raper DM, Ding D, Buell T, Mastorakos P, et al. Endovascular mechanical thrombectomy for cerebral venous sinus thrombosis: a systematic review. J Neurointerv Surg. 2017; 9 (11):1086–92. DOI: 10.1136/neurintsurg-2016-012938.
  13. McBane RD, Tafur A, Wysokinski WE. Acquired and congenital risk factors associated with cerebral venous sinus thrombosis. Thromb Res. 2010; 126 (2): 81–7. DOI: 10.1016/j.thromres.2010.04.015.
  14. Martinelli I, Cattaneo M, Taioli E, De Stefano V, Chiusolo P, Mannucci PM. Genetic risk factors for superficial vein thrombosis. Thromb Haemost. 1999; 82 (4): 1215–7. PMID: 10544900.
  15. Bushnell C, Saposnik G. Evaluation and management of cerebral venous thrombosis. Continuum (Minneap Minn). 2014; 20 (2 Cerebrovascular Disease): 335–51. DOI: 10.1212/01. CON.0000446105.67173.a8.
  16. Marjot T, Yadav S, Hasan N, Bentley P, Sharma P. Genes associated with adult cerebral venous thrombosis. Stroke. 2011; 42 (4): 913–8. DOI: 10.1161/STROKEAHA.110.602672.
  17. Ferro JM, Bousser MG, Canhão P, Coutinho JM, Crassard I, Dentali F, et al. European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis — Endorsed by the European Academy of Neurology. Eur Stroke J. 2017; 2 (3): 195–221. DOI: 10.1177/2396987317719364.
  18. Alshoabi SA. Cerebral venous sinus thrombosis: a diagnostic challenge in a rare presentation. Brain Circ. 2017; 3 (4): 227–230. DOI: 10.4103/bc.bc_27_17.
  19. Gao L, Xu W, Li T, Yu X, Cao S, Xu H, et al. Accuracy of magnetic resonance venography in diagnosing cerebral venous sinus thrombosis. Thromb Res. 2018; (167): 64–73. DOI: 10.1016/j. thromres.2018.05.012.
  20. Goyal G, Charan A, Singh R. Clinical Presentation, Neuroimaging Findings, and Predictors of Brain Parenchymal Lesions in Cerebral Vein and Dural Sinus Thrombosis: A Retrospective Study. Ann Indian Acad Neurol. 2018; 21 (3): 203–8. DOI: 10.4103/aian. AIAN_470_17.
  21. Cai H, Ye X, Zheng W, Ma L, Hu X, Jin X. Pitfalls in the diagnosis and initial management of acute cerebral venous thrombosis. Rev Cardiovasc Med. 2018; 19 (4): 129–33. DOI: 10.31083/j. rcm.2018.04.4081.
  22. Ferro JM, Canhão P, Aguiar de Sousa D. Cerebral Venous Thrombosis. Presse Med. 2016; 45 (12 Pt 2): e429–e450. PubMed PMID: 27816347. DOI: 10.1016/j.lpm.2016.10.007.
  23. Schneider S, Kapelushnik J, Kraus M, El Saied S, Levi I, Kaplan DM. The association between otogenic lateral sinus thrombosis and thrombophilia — A long-term follow-up. Am J Otolaryngol. 2018; 39 (3): 299–302. PubMed PMID: 29530427. DOI: 10.1016/j. amjoto.2018.03.013.
  24. Lichy C, Dong–Si T, Reuner K, Genius J, Rickmann H, Hampe T, et al. Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems. J Neurol. 2006; 253 (3): 316–20. PubMed PMID: 16155788. DOI: 10.1007/s00415-005-0988-4.
  25. Li B, Heldner MR, Arnold M, Coutinho JM, Zuurbier SM, Meijers JCM, et al. Coagulation Factor XIII in Cerebral Venous Thrombosis. TH Open. 2019; 3 (3): e227–e229. DOI: 10.1055/s- 0039-1693487.
  26. Bagoly Z, Muszbek L. Factor XIII: What does it look like? J Thromb Haemost. 2019; 17 (5): 714–6. DOI: 10.1111/jth.14431.
  27. Ali Z, Troncoso JC, Fowler DR. Recurrent cerebral venous thrombosis associated with heterozygote methylenetetrahydrofolate reductase C677T mutation and sickle cell trait without homocysteinemia: an autopsy case report and review of literature. Forensic Sci Int. 2014; (242): e52–e55. DOI: 10.1016/j.forsciint.2014.07.007.
  28. Ghaznavi H, Soheili Z, Samiei S, Soltanpour MS. Association study of methylenetetrahydrofolate reductase C677T mutation with cerebral venous thrombosis in an Iranian population. Blood Coagul Fibrinolysis. 2015; 26 (8): 869–73. DOI: 10.1097/ MBC.0000000000000292.