ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Taxonomic dysbiosis of gut microbiota and serum biomarkers reflect severity of central nervous system injury
About authors
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
Correspondence should be addressed: Ekaterina A. Chernevskaya
Petrovka, 25, s. 2, Moscow, 127051; ur.rrcknf@ayaksvenrehce
About paper
Compliance with ethical standards: the study was approved by the Ethics Committee of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology (Protocol № 2/19/2 dated June 20, 2019). Informed consent was obtained from all study participants or their legal representatives.
Author contribution: Chernevskaya EA, Meglei AYu — taxonomic microbiota profiling, serum biomarker tests, data analysis, manuscript preparation; Beloborodova NV — study design, final version of the manuscript; Buyakova IV, Kovaleva NYu, Gorshkov KM — patient recruitment and treatment, clinical data collection; ZakharchenkoVE — sample collection, final version of the manuscript. All authors read and approved the final version of the manuscript.
Received: 2020-08-20
Accepted: 2020-09-03
Published online: 2020-09-17
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Fig. 1. The taxonomic composition of the gut microbiota in conscious patients (n = 19) and vegetative state patients (n = 10) compared to the reference ranges (shown in blue) provided by the manufacturer. Twenty parameters were compared
Fig. 2. Association between the CRP/albumin ratio and GCS scores (p < 0.05 for comparison of the groups that scored 15 and 12–6 points)
Fig. 3. Blood serums concentrations of IL6 and cortisol in patients with different GCS scores (p < 0.05 for comparison between groups scoring 15 and 14–13 points and between groups scoring 15 and 12–6 points)
Table 1. Patient characteristics. MV — mechanical ventilation, TST — tracheostomy tube, ACVE — acute cerebrovascular event, TBI — traumatic brain injury
Table 2. Taxonomic abundance of the gut microbiota in patients receiving or not receiving antibacterial therapy
Table 3. Blood serum parameters in patients with CCI
Note: * — differences are statistically significant.
