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ORIGINAL RESEARCH
Models of mitochondrial dysfunction with inducible expression of Polg pathogenic mutant variant
1 Institute of Gene Biology, Moscow, Russia
2 Blokhin Russian Cancer Research Center, Moscow, Russia
Correspondence should be addressed: Marina V. Kubekina
Beskudnikovsky bulvar, 32, korpus 1, Moscow, 127474, Russia; moc.liamg@ymukyram
Funding: the study was supported by Russian Foundation for Basic Research, RFBR Project № 19-34-90073.
Author contribution: Kubekina MV — literature analysis, experimental research, data analysis and interpretation, oligo design, manuscript writing; Kalinina AA, Korshunova DS — experimental research; Bruter AV — literature analysis, research planning, data analysis and interpretation; Silaeva YY — literature analysis, research planning, data analysis and interpretation, scientific editing of the manuscript.
Compliance with ethical standards: the study was approved by Ethical Review board at the Institute of Gene Biology (Protocol of 05 December 2021) and carried out in strict compliance with the Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes.



