2022 / 05

Next Paper
DOI: 10.24075/brsmu.2022.048

ORIGINAL RESEARCH

Antiphospholipid antibodies and outcomes of assisted reproductive technology programs in patients with a history of COVID-19

Ermakova DM, Dolgushina NV, Menzhinskaya IV, Lomova NA, Vtorushina VV
About authors

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

Correspondence should be addressed: Irina V. Menzhinskaya
Akademika Oparina, 4, Moscow, 117997, Russia; ur.4anirapo@ayaksniznem_i

About paper

Funding: the work was supported by the Vklad v buduscheye (Investment in the Future) charity foundation as part of the Stop Coronavirus Together program-campaign.

Author contribution: Ermakova DM, Lomova NA — management of patients participating in the study, article authoring; Dolgushina NV — collection and analysis of literature data, manuscript editing, statistical data analysis; Menzhinskaya IV — execution of the laboratory part of the study, article authoring and editing; Vtorushina VV — execution of the laboratory part of the study

Compliance with ethical standards: the study was approved by the Ethics Committee of Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology (Minutes of meeting № 12 of November 26, 2020); all patients signed an informed voluntary consent to participation in the study.

Received: 2022-09-07 Accepted: 2022-09-30 Published online: 2022-10-31
|
  1. Bentov Y, Beharier O, Moav-Zafrir A, Kabessa M, Godin M, Greenfield CS, et al. Ovarian follicular function is not altered by SARS–CoV-2 infection or BNT162b2 mRNA COVID-19 vaccination. Hum Reprod. 2021; 36 (9): 2506–13.
  2. Wang M, Yang Q, Ren X, Hu J, Li Z, Long R, et al. Investigating the impact of asymptomatic or mild SARS-CoV-2 infection on female fertility and in vitro fertilization outcomes: A retrospective cohort study. E Clinical Medicine. 2021; 38: 101013. DOI: 10.1016/j. eclinm.2021.101013.
  3. Mullins E, Perry A, Banerjee J, Townson J, Grozeva D, Milton R, et al. Pregnancy and neonatal outcomes of COVID-19: The PANCOVID study. Eur J Obste. Gynecol Reprod Biol. 2022; 276: 161–7.
  4. Allotey J, Stallings E, Bonet M, Yap M, Chatterjee S, Kew T, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: Living systematic review and meta-analysis. BMJ. 2020; 370: m3320. DOI: 10.1136/bmj.m3320.
  5. Balachandren N, Davies MC, Hall JA, Stephenson JM, David AL, Barrett G, et al. SARS-CoV-2 infection in the first trimester and the risk of early miscarriage: a UK population-based prospective cohort study of 3041 pregnancies conceived during the pandemic. Hum. Reprod. 2022; 37 (6): 1126–33.
  6. Bechmann N, Maccio U, Kotb R, Dweik RAl, Cherfane M, Moch H, et al. COVID-19 Infections in Gonads: Consequences on Fertility? Horm Metab Res. 2022; 54 (08): 549–55.
  7. Hu W, Zhu Y, Wu Y, Wang F, Qu F. Impact of COVID-19 pandemic on the pregnancy outcomes of women undergoing assisted reproductive techniques (ARTs): a systematic review and metaanalysis. J Zhejiang Univ Sci B. 2022; 23 (8): 655–65.
  8. Youngster M, Avraham S, Yaakov O, Landau Rabbi M, Gat I, Yerushalmi G, et al. IVF under COVID-19: treatment outcomes of fresh ART cycles. Hum Reprod. 2022; 37 (5): 947–53.
  9. Maiorino MI, Bellastella G, Giugliano D, Esposito K. From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome. J Endocrinol Invest. 2018; 41 (11): 1249–58.
  10. Huang C, Ji X, Zhou W, Huang Z, Peng X, Fan L, et al. Coronavirus: A possible cause of reduced male fertility. Andrology. 2021; 9 (1): 80–7.
  11. Matyushkina D, Shokina V, Tikhonova P, Manuvera V, Shirokov D, Kharlampieva D, et al. Autoimmune Effect of Antibodies against the SARS-CoV-2 Nucleoprotein. Viruses. 2022; 14 (6): 1141.
  12. Knight JS, Caricchio R, Casanova J-L, Combes AJ, Diamond B, Fox SE, et al. The intersection of COVID-19 and autoimmunity. J Clin Invest. 2021; 131 (24): e154886. DOI: 10.1172/JCI154886.
  13. Mohkhedkar M, Venigalla SSK, Janakiraman V. Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement. Mol Immunol. 2021; 137: 105–13.
  14. Sacchi MC, Tamiazzo S, Stobbione P, Agatea L, De Gaspari P, Stecca A, et al. SARS-CoV-2 infection as a trigger of autoimmune response. Clin Transl Sci. 2021; 14 (3): 898–907.
  15. Lui DTW, Lee CH, Chow WS, Lee ACH, Tam AR, Pang P, et al. Long COVID in Patients With Mild to Moderate Disease: Do Thyroid Function and Autoimmunity Play a Role? Endocr Pract. 2021; 27 (9): 894–902.
  16. Ehrenfeld M, Tincani A, Andreoli L, Cattalini M, Greenbaum A, Kanduc D, et al. Covid-19 and autoimmunity. Autoimmun. Rev. 2020; 19 (8): 102597. DOI: 10.1016/j.autrev.2020.102597.
  17. Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W, et al. Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19. N Engl J Med. 2020; 382 (17): e38. DOI: 10.1056/ NEJMc2007575.
  18. Harzallah I, Debliquis A, Drénou B. Lupus anticoagulant is frequent in patients with Covid-19. J Thromb Haemost. 2020; 18 (8): 2064–5.
  19. Soriano A, Blank M, Shoenfeld Y. Genetics and origin of antiphospholipid syndrome. In: Meroni PL, editor. Antiphospholipid antibody syndrome. From bench to bedside. Cham: Springer I, 2014; p. 1–12.
  20. Khizroeva J, Nalli C, Bitsadze V, Lojacono A, Zatti S, Andreoli L, Tincani A, Shoenfeld Y, Makatsariya A. Infertility in women with systemic autoimmune diseases. Best Practice & Research Clinical Endocrinology & Metabolism. 2019; 33 (6): 101369. Available from: https://doi.org/10.1016/j.beem.2019.101369.
  21. Chighizola СВ, de Jesus GR, Branch DW. The hidden world of anti-phospholipid antibodies and female infertility: A literature appraisal. Autoimmunity Reviews. 2016; 15 (6): 493–500. Available from: https://doi.org/10.1016/j.autrev.2016.01.018.
  22. Kolanska K, Hours A, Jonquière L, Mathieu d’Argent E, Dabi Y, et al. Mild COVID-19 infection does not alter the ovarian reserve in women treated with ART. Reprod Biomed Online. 2021; 43 (6): 1117–21.
  23. Aharon D, Gounko D, Lee JA, Copperman AB, Flisser E. The Impact of the Coronavirus Disease 19 Pandemic on Early Pregnancy Outcomes Among Patients Undergoing In Vitro Fertilization Treatment. Women’s Heal Reports. 2021; 2 (1): 473–8.
  24. Setti PEL, Cirillo F, Immediata V, Morenghi E, Canevisio V, Ronchetti C, et al. First trimester pregnancy outcomes in a large IVF center from the Lombardy County (Italy) during the peak COVID-19 pandemic. Sci Rep. 2021; 11 (1): 16529. DOI: 10.1038/s41598-021-96134-9.
  25. Madaan S, Jaiswal A, Kumar S, Talwar D. Premature ovarian failure-A long COVID sequelae. Med Sci. 2021; 25 (112): 1286–90.
  26. Wilkins J, Al-Inizi S. Premature ovarian insufficiency secondary to COVID–19 infection: An original case report. Int J Gynecol Obstet. 2021; 154 (1): 179–80.
  27. Shams T, Alhashemi H, Madkhali A, Noorelahi A, Allarakia S, Faden Y, et al. Comparing pregnancy outcomes between symptomatic and asymptomatic COVID-19 positive unvaccinated women: Multicenter study in Saudi Arabia. J Infect Public Health. 2022; 15 (8): 845–52.
  28. Caso F, Costa L, Ruscitti P, Navarini L, Del Puente A, Giacomelli R, et al. Could Sars-coronavirus-2 trigger autoimmune and/or autoinflammatory mechanisms in genetically predisposed subjects? Autoimmun Rev. 2020; 19 (5): 102524. DOI: 10.1016/j. autrev.2020.102524.
  29. Dolgushina NV, Menzhinskaya IV, Beznoshchenko OS, Mullabaeva SM, Gorodnova EA, Krechetova LV. Profil antifosfolipidnyx antitel i sostoyanie sistemy komplementa u bol'nyx COVID-19 raznoj stepeni tyazhesti. Medicinskaya immunologiya. 2022; 24 (2): 355–370. Medical immunology. 2022; 24 (2): 355-370. Russian.