Acknowledgements: the authors express their gratitude to all the patients enrolled for their active cooperation and thank the physicians and nurses at the Diagnostic Clinical Center No. 1 of the Moscow Department of Health.

Author contribution: Poryadin GV, Larina VN — study concept and design; Ryzhikh AA, Stodelova EA — data acquisition and processing; Stodelova EA, Kazimirskii AN — experimental studies, preparation of illustrations; Panina MI — statistical data processing; Kazimirskii AN — manuscript writing; Salmasi JM, Panina MI — editing.

Compliance with ethical standards: the study was approved by the Ethics Committee at the Pirogov Russian National Research Medical University (protocol № 203 of 21 December 2021); all patients submitted the informed consent to study participation.