ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Adipokines and myokines as indicators of obese phenotypes and their association with the gut microbiome diversity indices
About authors
1 Rostov State Medical University, Rostov-on-Don, Russia
2 Center for Molecular Health, Institute of Digital and Translational Biomedicine, Moscow, Russia
3 Pirogov Russian National Research Medical University, Moscow, Russia
4 Kazan Federal University, Kazan, Republic of Tatarstan, Russia
Correspondence should be addressed: Lilia A. Ganenko
Nakhichevansky pereulok, 29, Rostov-on-Don, 344022, Russia; ur.xednay@ailil.oknenag
About paper
Funding: the study was conducted as part of the State Assignment № 0373100122119000041, the project “Creation of a bank of blood serum and fecal samples from healthy donors and patients with obesity, metabolic syndrome, type 2 diabetes mellitus, impaired mucosal barrier of the gastrointestinal tract with the aim of identifying candidate species-specific mediators of quorum sensing microbiota systems human modulating endocrine and metabolic function of adipose tissue”.
Author contribution: Ganenko LA — study concept, data acquisition and analysis, manuscript writing; Volkova NI — research planning and management, manuscript editing; Roumiantsev SA — study design, manuscript editing; Grigoryeva TV — working with the database, analysis of the results; Laikov AV — data analysis and interpretation of the results; Vasilyev IYu — study concept, manuscript editing; Gaponov AM — literature review, study design, manuscript editing; Naboka YuL — data analysis and interpretation of the results, manuscript editing; Shestopalov AV — search for sources of funding, working with data sets, statistical data processing, manuscript writing.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Rostov State Medical University (protocol № 20/19 of 12 December 2019); the informed consent was submitted by all study participants.
Received: 2022-12-19
Accepted: 2023-01-21
Published online: 2023-02-17
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Fig. 1. Clustermap of the correlations between glucose, adipokines, myokines, lipid profile and the gut microbiome diversity indicators for the group of patients with MHO
Fig. 2. Clustermap of the correlations between glucose, adipokines, myokines, lipid profile and the gut microbiome diversity indicators for the group of patients with MUO
Table 1. Clinical and laboratory characteristics of the surveyed individuals of groups 1 and 2
Note: BMI — body mass index, WC — waist circumference, SBP — systolic blood pressure, DBP — diastolic blood pressure, TC — total cholesterol, LDL-C — low density lipoprotein cholesterol, HDL-C — high density lipoprotein cholesterol, TG — triglycerides, НОМА-IR — Homeostasis Model Assessment of Insulin Resistance.
Table 2. Clinical and laboratory characteristics of the surveyed individuals of subgroups 2а and 2b
Note: BMI — body mass index, WC — waist circumference, SBP — systolic blood pressure, DBP — diastolic blood pressure, TC — total cholesterol, LDL-C — low density lipoprotein cholesterol, HDL-C — high density lipoprotein cholesterol, TG — triglycerides, НОМА-IR — Homeostasis Model Assessment of Insulin Resistance.
Table 3. Serum levels of adipokines and myokines in healthy individuals and obese patients
Table 4. Serum levels of adipokines and myokines in subjects of the group 1 subgroups 2а and 2b
Table 5. Characteristics of the stool microbiome alpha diversity in the studied groups of patients
Note: the data are presented as median and 95% confidence interval; * — significant differences from group 1 (р < 0.05); † — significant differences from patients with MHO (р < 0.05)
