ORIGINAL RESEARCH
Adipokines and myokines as indicators of obese phenotypes and their association with the gut microbiome diversity indices
1 Rostov State Medical University, Rostov-on-Don, Russia
2 Center for Molecular Health, Institute of Digital and Translational Biomedicine, Moscow, Russia
3 Pirogov Russian National Research Medical University, Moscow, Russia
4 Kazan Federal University, Kazan, Republic of Tatarstan, Russia
Correspondence should be addressed: Lilia A. Ganenko
Nakhichevansky pereulok, 29, Rostov-on-Don, 344022, Russia; ur.xednay@ailil.oknenag
Funding: the study was conducted as part of the State Assignment № 0373100122119000041, the project “Creation of a bank of blood serum and fecal samples from healthy donors and patients with obesity, metabolic syndrome, type 2 diabetes mellitus, impaired mucosal barrier of the gastrointestinal tract with the aim of identifying candidate species-specific mediators of quorum sensing microbiota systems human modulating endocrine and metabolic function of adipose tissue”.
Author contribution: Ganenko LA — study concept, data acquisition and analysis, manuscript writing; Volkova NI — research planning and management, manuscript editing; Roumiantsev SA — study design, manuscript editing; Grigoryeva TV — working with the database, analysis of the results; Laikov AV — data analysis and interpretation of the results; Vasilyev IYu — study concept, manuscript editing; Gaponov AM — literature review, study design, manuscript editing; Naboka YuL — data analysis and interpretation of the results, manuscript editing; Shestopalov AV — search for sources of funding, working with data sets, statistical data processing, manuscript writing.
Compliance with ethical standards: the study was approved by the Ethics Committee of the Rostov State Medical University (protocol № 20/19 of 12 December 2019); the informed consent was submitted by all study participants.
- Frühbeck G, Catalán V, Rodríguez A, Gómez-Ambrosi J. Adiponectin-leptin ratio: A promising index to estimate adipose tissue dysfunction. Relation with obesity-associated cardiometabolic risk. Adipocyte. 2018; 7 (1): 57–62. DOI: 10.1080/21623945.2017.1402151.
- Iacobini C, Pugliese G, Blasetti Fantauzzi C, at al. Metabolically healthy versus metabolically unhealthy obesity. Metabolism. 2019; 92: 51–60. DOI: 10.1016/j.metabol.2018.11.009.
- Smith GI, Mittendorfer B, Klein S. Metabolically healthy obesity: facts and fantasies. J Clin Invest. 2019; 129 (10): 3978–89. DOI: 10.1172/JCI129186.
- Garvey WT, Garber AJ, Mechanick JI, et al. The Aace Obesity Scientific Committee.American association of clinical endocrinologists and Аmerican college of endocrinology position statement on the 2014 advanced framework for a new diagnosis of obesity as a chronic disease. Endocr Pract. 2014; 20 (9): 977– 89. DOI: 10.4158/EP14280.PS.
- Graf C, Ferrari N. Metabolic Health-The Role of AdipoMyokines. Int J Mol Sci. 2019; 20 (24): 6159. DOI: 10.3390/ijms20246159.
- Bakhai A. Adipokines--targeting a root cause of cardiometabolic risk. QJM. 2008; 101 (10): 767–76. DOI: 10.1093/qjmed/hcn066.
- Doumatey AP, Bentley AR, Zhou J, Huang H, Adeyemo A, Rotimi CN. Paradoxical Hyperadiponectinemia is Associated With the Metabolically Healthy Obese (MHO) Phenotype in African Americans. J Endocrinol Metab. 2012; 2 (2): 51–65. DOI: 10.4021/jem95W.
- Bluher S. Metabolically healthy obesity from childhood to adulthood — does weight status alone matter? Metabolism. 2014; 63: 1084–109.
- Wang HY. Plasma asprosin concentrations are increased in individuals with glucose dysregulation and correlated with insulin resistance and first-phase insulin secretion. Mediators of Inflammation. 2018; ID 9471583.
- Amor M, Itariu BK, Moreno-Viedma V, Keindl M, Jürets A, Prager G, et al. Serum Myostatin is Upregulated in Obesity and Correlates with Insulin Resistance in Humans. Exp Clin Endocrinol Diabetes. 2019; 127 (8): 550–6.
- Staiger H, Keuper M, Berti L, Hrabe de Angelis M, Häring HU. Fibroblast Growth Factor 21-Metabolic Role in Mice and Men. Endocr Rev. 2017; 38 (5): 468–88.
- Hu C, Zhang X, Zhang N, Wei WY, Li LL, Ma ZG, et al. Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin-induced cardiotoxicity. Clin Transl Med. 2020; 10 (3): e124.
- Fu J, Li Y, Esangbedo IC, Li G, Feng D, Li L, et al. Circulating Osteonectin and Adipokine Profiles in Relation to Metabolically Healthy Obesity in Chinese Children: Findings From BCAMS. J Am Heart Assoc. 2018; 7 (23): e009169. DOI: 10.1161/ JAHA.118.009169.
- Rinninella E, Raoul P, Cintoni M, Franceschi F, Miggiano GAD, Gasbarrini A, et al. What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases. Microorganisms. 2019; 7 (1): 14. DOI: 10.3390/microorganisms7010014.
- Stoma IO, Karpov IA. Mikrobiom cheloveka. Minsk: Doktor Dizajn, 2018; 122 s. Russian.
- Bombin A, Yan S, Bombin S, Mosley JD, Ferguson JF. Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa. Physiological Reports. 2022; 10: e15254. Available from: https://doi.org/10.14814/phy2.15254.
- Aron-Wisnewsky J, Prifti E, Belda E, et al. Major microbiota dysbiosis in severe obesity: fate after bariatric surgery. Gut. 2019; 68 (1): 70–82. DOI: 10.1136/gutjnl-2018-316103.
- Cotillard A, Kennedy SP, Kong LC, Edi Prifti, Nicolas Pons, Emmanuelle Le Chatelier, et al. Dietary intervention impact on gut microbial gene richness. Nature. 2013; 500 (7464): 585–8. DOI: 10.1038/nature12480. Erratum in: Nature. 2013; 502 (7472) 580.
- Everard A, Belzer C, Geurts L, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls dietinduced obesity. Proc Natl Acad Sci USA. 2013; 110 (22): 9066– 71. DOI: 10.1073/pnas.1219451110.
- Menshikov VV, redaktor. Metodiki klinicheskix laboratornyx issledovanij. Spravochnoe posobie. Tom 3. M.: Labora, 2009; 880 s. Russian.
- Gaponov AM, Volkova NI, Ganenko LA, Naboka YuL, Markelova MI, Sinyagina MN, i dr. Osobennosti mikrobioma tolstoj kishki u pacientov s ozhireniem pri ego razlichnyx fenotipax. Zhurnal mikrobiologii, ehpidemiologii i immunobiologii. 2021; 98 (2): 144–155. Dostupno po ssylke: https://doi.org/10.36233/0372-9311-66. Russian.
- Kolesnikova IM, Gaponov AM, Ganenko LA, Volkova NI, Grigoreva TV, Lajkov AV, i dr. Vzaimosvyaz' soderzhaniya nejrotrofov kishechnogo mikrobioma pri razlichnyx metabolicheskix tipax ozhireniya. Zhurnal ehvolyucionnoj bioximii i fiziologii. 2022; 58 (54): 298–310. Russian.
- Yosaee S, Khodadost M, Esteghamati A, et al. Adiponectin: An Indicator for Metabolic Syndrome. Iran J Public Health. 2019; 48 (6): 1106–15.
- Gustafson B, Hedjazifar S, Gogg S, Hammarstedt A, Smith U. Insulin resistance and impaired adipogenesis. Trends Endocrinol Metab. 2015; 26 (4): 193–200. DOI: 10.1016/j.tem.2015.01.006.
- Izquierdo AG, Crujeiras AB, Casanueva FF, Carreira MC. Leptin, obesity, and leptin resistance: where are we 25 years later? Nutrients. 2019; 11 (11): 2704. DOI: 10.3390/nu11112704.
- Yuan M, Li W, Zhu Y, et al. Asprosin: A novel player in metabolic diseases. Front Endocrinol (Lausanne). 2020; 11: 64. DOI: 10.3389/fendo.2020.00064.
- Ugur K, Aydin S. Saliva and blood asprosin hormone concentration associated with obesity. Int J Endocrinol. 2019; 2019: 2521096. DOI: 10.1155/2019/2521096.
- Elisha B, Karelis AD, Imbeault P, et al. Effects of acute hyperinsulinaemia on total and high-molecular-weight adiponectin concentration in metabolically healthy but obese postmenopausal women: a Montreal-Ottawa New Emerging Team (MONET) study. Diabetes Metab. 2010; 36 (4): 319–21. DOI: 10.1016/j.diabet.2010.03.004.
- Ung UJ, Choi M-S. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. International Journal of Molecular Sciences. 2014; 15 (4): 6184–223. Available from: https://doi.org/10.3390/ijms15046184111,112.
- Jamar G, Caranti DA, de Cassia Cesar H, et al. Leptin as a cardiovascular risk marker in metabolically healthy obese: Hyperleptinemia in metabolically healthy obese. Appetite. 2017; 108: 477–82. DOI: 10.1016/j.appet.2016.11.013.
- Fu J, Li Y, Esangbedo IC. et al. Circulating osteonectin and adipokine profiles in relation to metabolically healthy obesity in chinese children: findings from BCAMS. J Am Heart Assoc. 2018; 7 (23): e009169. DOI: 10.1161/JAHA.118.009169.