2023 / 02

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DOI: 10.24075/brsmu.2023.011

ORIGINAL RESEARCH

Effects of the metaplasticity-based theta-burst transcranial stimulation protocols on working memory performance

Bakulin IS, Zabirova AH, Poydasheva AG, Sinitsyn DO, Lagoda DYu, Suponeva NA, Piradov MA
About authors

Research Center of Neurology, Moscow, Russia

Correspondence should be addressed: Alfiia H. Zabirova
Volokolamskoye shosse, 80, Moscow, 125367, Russia; moc.liamg@aworibasajifla

About paper

Funding: the study was supported by the Russian Science Foundation (RSF), grant № 21-75-00040, https://rscf.ru/en/project/21-75-00040/.

Author contribution: Bakulin IS, Zabirova AH — study planning and design; Bakulin IS, Zabirova AH, Poydasheva AG, Lagoda DYu — experimentation and data acquisition; Bakulin IS, Zabirova AH, Sinitsyn DO — data analysis; all authors — data interpretation; Bakulin IS, Zabirova AH — writing the draft of the manuscript; all authors — manuscript editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Center of Neurology (protocol № 8-8/21 of 15 September 2021), it was conducted in accordance with the principles of the Declaration of Helsinki. The informed consent was submitted by all study participants.

Received: 2023-03-24 Accepted: 2023-04-14 Published online: 2023-04-25
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Fig. 1. А. Study design. B. Theta-burst stimulation protocols
Fig. 2. Percentage of participants with various types of response to TMS protocols (А for n = 2, B for n = 3, C for n = 4). Facilitation is highlighted in orange, inhibition in blue, and no response in grey
Table 1. The effects of iTBS protocols on the n-back test accuracy
Note: Т2–T1 — median difference (d’) between Т2 and Т1; Т3–Т1 — between Т3 and Т1; uncorrected р-values are provided.
Table 2. P-values for comparison of the number of subjects with various response types between protocols (uncorrected)
Table 3. Correlation of the effects of two iterations of the combination of active stimulation block with the vertex stimulation (Т2 in the iTBS 0–60 and iTBS 0 protocols) with the n-back test accuracy
Note: ρ — Spearman's rank correlation coefficient, р — uncorrected p-value.
Table 4. Association analysis of the direction of responses to two iterations of the combination of active stimulation block with the vertex stimulation (Т2 in the iTBS 0–60 and iTBS 0 protocols)
Note: uncorrected p-values are provided (Fisher's exact test).