![](/i/rsmu-medium-clean.png)
ORIGINAL RESEARCH
Possible links of wildfires with oncological diseases of children and adults in the Russian Far East
1 Khabarovsk Federal Research Center, Far Eastern branch of the Russian Academy of Sciences, Khabarovsk, Russia
2 Tsinghua University, Beijing, China
3 The Southern Scientific Centre of the Russian Academy of Sciences, Rostov-on-Don, Russia
4 The University of Hong Kong, Hong Kong
5 National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation. Moscow, Russia
6 Peoples’ Friendship University of Russia, Moscow, Russia
7 Burnazyan Federal Medical Biophysical Center of the Federal Medical and Biological Agency, Moscow, Russia
8 Far Eastern State Medical University, Khabarovsk, Russia
Correspondence should be addressed: Sergey K. Pinaev
Muravyova-Amuskogo, 35, Khabarovsk, 680000, Russia; ur.liam@veanip
Acknowledgments: we thank Professor N.E. Kosykh from Far Eastern Medical University for their help in collecting data on the updated incidence of malignant neoplasms in children in Khabarovskij Kraj. We acknowledged Olga P. Gretsova for preparing the data for analysis. S. Venevsky acknowledges the support from the Russian State Assignment of the Federal Research Centre of the Southern Scientific Centre of the Russian Academy of Sciences (SSC RAS) (122013100131-9) and Department of Earth System Sciences of Tsinghua University.
Author contribution: Pinaev SK — author of the general idea and the main design of the study, collection and analysis of data, and formation of hypotheses; Venevsky S — developed method of spatial and non-linear temporal analysis, presentation and interpretation of results of this analysis and made conclusions; Chakov VV — collection and analysis of information about the fire situation in the Far Eastern Federal district on the basis of data presented in the public domain; Linwei Tian — run ARIMA analysis; Chizhov AYa, Peng Gong, Pinaeva OG — participated in the planning of the study and discussion of the results; Kaprin AD, Venevsky S — Participation in research planning and formation of data on CI based on the national cancer registry of Russia; Venevsky S, Pinaev SK — wrote the manuscript.
- Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal AD, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians. 2021; 71: 209–49. PubMed PMID: 33538338.
- Amin RW, Stafford B, Guttmann RP. A spatial study of bladder cancer mortality and incidence in the contiguous US: 2000–2014. Science of The Total Environment 2019; 670: 806–13.
- Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, et al. Global Burden of Disease Cancer Collaboration; Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability Adjusted Life-years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncology. 2017; 3 (4): 524–48. PubMed PMCID: PMC6103527.
- ONCOLOGY.RU Zlokachestvennye novoobrazovaniya v Rossii. Dostupno po ssylke: http://www.oncology.ru/service/statistics/malignant_tumors/ (dostup: 17.01.2023). Russian.
- Dobroxleb VG. Starenie naseleniya Rossii: regional'nyj aspekt // Voprosy territorial'nogo razvitiya. 2018; 4 (44). DOI: 10.15838/ tdi.2018.4.44.4. Russian.
- Lupyan EA, Bartalev SA, Balashov IV, Egorov VA, Ershov DV, Kobec DA, i dr. Sputnikovyj monitoring lesnyh pozharov v 21 veke na territorii Rossijskoj Federacii (cifry i fakty po dannym detektirovaniya aktivnogo goreniya). Sovremennye problemy distancionnogo zondirovaniya Zemli iz kosmosa. 2017; 14 (6): 158–75. DOI: 10.21046/2070-7401-2017-14-6-158-175. Russian.
- Navarroa KM, Kleinmanb MT, Mackayc CE, Reinhardtd TE, Balmese JR, Broylesf GA, et al. Wildland firefighter smoke exposure and risk of lung cancer and cardiovascular disease mortality. Environmental Research. 2019; 173: 462–8. PubMed PMID: 30981117.
- ROSGIDROMET. Obzor sostoyaniya i zagryazneniya okruzhayushhej sredy v Rossijskoj Federacii. Dostupno po ssylke: https://www.meteorf.gov.ru/product/infomaterials/90/. Russian.
- Gambaryan MG, Drapkina OM. Rasprostranennost' potrebleniya tabaka v Rossii: dinamika i tendencii. Analiz rezul'tatov global'nyx i nacional'nyh oprosov. Profilakticheskaya medicina. 2018; 21 (5): 45–62. DOI: 10.17116/profmed20182105145. Russian.
- Reid CE, Brauer M, Johnston FH, Jerrett M, Balmes JR, Elliott CT. Critical review of health impacts of wildfire smoke exposure. Environmental health perspectives. 2016; 124 (9): 1334–43. PubMed PMID: 27082891.
- Turner MC, Krewski D, Diver WR, Pope III CA, Burnett RT, Jerrett M, et al. Ambient air pollution and cancer mortality in the cancer prevention study II. Environmental health perspectives. 2017; 125 (8): 087013. PubMed PMID: 28886601.
- Dobrykh VA, Zakharycheva TA. Forest fire smoke and health. Khabarovsk: Publishing House of the Far Eastern State Medical University, 2009. 201 p. ISBN 5-85797-172-1. http://www.fesmu.ru/elib/PdfViewer/default.aspx?id=33&res=1366%2c657.
- Korsiak J, Pinault L, Christidis T, Burnett RT, Abrahamowicz M, Weichenthal S. Long-term exposure to wildfires and cancer incidence in Canada: a population-based observational cohort study. The Lancet Planetary Health. 2022; 6 (5): e400–e9. PubMed PMID: 35550079.
- Chizhov AYa, Pinaev SK. Sistemnyj analiz vliyaniya solnechnoj radiacii i dyma lesnyh pozharov na risk lejkoza u detej. Radiaciya i risk. 2018; 27 (4): 87–94. DOI: 10.21870/0131-3878-201827-4-87-94. Russian.
- Pinaev SK, Chizhov AYa, Pinaeva OG. Svyaz' dyma i solnechnoj aktivnosti s novoobrazovaniyami cheloveka. Kazanskij medicinskij zhurnal. 2022; 103 (4): 650–7. DOI: 10.17816/KMJ2022-650. Russian.
- Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P. International Classification of Childhood Cancer, third edition. Cancer. 2005; 103 (7): 1457–67. DOI: 10.1002/cncr.20910. PubMed PMID: 15712273.
- Bleyer A, Barr R, Ries J, Whelan A, Ferrari, editors. Cancer in Adolescents and Young Adults: Pediatric Oncology: Springer International Publishing AG; 2017. DOI: 10.1007/978-3-31933679-4.
- Botsivali M, Kyrtopoulos SA. Transplacental exposure to carcinogens and risks to children: evidence from biomarker studies and the utility of omic profiling. Archives of Toxicology. 2019; 93 (4): 833–57. PubMed PMID: 30859261.
- Ponomarev EI. Estimation of Direct Fire Emissions from Forests Burning in Siberia. Environmental Sciences Proceedings. 2021; 4 (1): 12. PubMed PMID: DOI: 10.3390/ecas2020-08114. PubMed PMID: 35513193.
- Box GEP, Jenkins GM, Reinsel GC, Ljung GM. Time series analysis. Forecasting and control. Wiley, 2016; p. 712. DOI: 10.1111/jtsa.12194.
- Jesus CSLd, Delgado RC, Wanderley HS, Teodoro PE, Pereira MG, Lima M, et al. Fire risk associated with landscape changes, climatic events and remote sensing in the Atlantic Forest using ARIMA model. Remote Sensing Applications: Society and Environment 2022; 26: 100761.
- Arul E, Sue ME, Fanny S, Jeremy M. Forecasting annual incidence and mortality rate for prostate cancer in Australia until 2022 using autoregressive integrated moving average (ARIMA) models. BMJ Open. 2019; 9: e031331.
- Wikén I, Andersson TML, Radkiewicz C. Seasonal effects on cancer incidence and prognosis. Acta Oncologica. 2023; 62: 103–9.
- Lin C, Labzovskii LD, Mak HWL, Fung JC, Lau AK, Kenea ST, et al. Observation of PM2. 5 using a combination of satellite remote sensing and low-cost sensor network in Siberian urban areas with limited reference monitoring. Atmospheric Environment. 2020; 227: 117410. DOI: 10.1016/j.atmosenv.2020.117410.
- Shaposhnikov D, Revich B, Bellander T, Bedada GB, Bottai M, Kharkova T, et al. Mortality related to air pollution with the Moscow heat wave and wildfire of 2010. Epidemiology (Cambridge, Mass). 2014; 25 (3): 359–64. PubMed PMID: 24598414.
- Hayes JD, Dinkova-Kostova TA, Tew KD. Oxidative Stress in Cancer. Cancer Cell. 2020; 38 (2): 167–97. PubMed PMID: 32649885.
- Bassig BA, Lan Q, Rothman N, Zhang Y, Zheng T. Current Understanding of Lifestyle and Environmental Factors and Risk of Non-Hodgkin Lymphoma: An Epidemiological Update. Journal of Cancer Epidemiology. 2012; 2012: 978930. PubMed PMID: 23008714.
- Naumova AS, Tiganova OA, Kondratchik KL. Rol' virusa Ehpshtejna– Barr v patogeneze limfomy Xodzhkina u detej. Pediatriya. 2019; 98 (1): 178–85. Russian.
- Greaves M. A causal mechanism for childhood acute lymphoblastic leukaemia. Nature Reviews Cancer. 2018; 18 (8): 471–4. PubMed PMID: 29784935.
- Cárceles-Álvarez A, Ortega-García JA, López-Hernández FA, Orozco-Llamas M, Espinosa-López B, Tobarra-Sánchez E, et al. Spatial clustering of childhood leukaemia with the integration of the Paediatric Environmental History. Environmental Research. 2017; 156: 605–12. PubMed PMID: 28454012.
- Marino-Enriquez A, Fletcher CDM. Shouldn't we care about the biology of benign tumours? Nature Reviews Cancer. 2014; 14: 701–2.