2023 / 06

Next Paper
DOI: 10.24075/brsmu.2023.045

ORIGINAL RESEARCH

Prefrontal cortex transcranial theta-burst stimulation frequency-dependent effects on cognitive functions

Suponeva NA, Bakulin IS, Poydasheva AG, Sinitsyn DO, Zabirova AH, Lagoda DYu, Piradov MA
About authors

Research Center of Neurology, Moscow, Russia

Correspondence should be addressed: Alexandra G. Poydasheva
Volokolamskoye shosse, 80, Moscow, 125310, Russia; ur.ygoloruen@avehsadyop

About paper

Funding: the study was supported by the Russian Science Foundation (RSF), grant № 22-25-00078, https://www.rscf.ru/project/22-25-00078/

Author contribution: Suponeva NA, Bakulin IS, Poydasheva AG, Piradov MA — study concept; Suponeva NA, Bakulin IS, Poydasheva AG, Sinitsyn DO, Piradov MA — study planning and design; Bakulin IS, Poydasheva AG, Zabirova AH, Lagoda DYu — research procedure and data acquisition; Bakulin IS, Poydasheva AG, Sinitsyn DO, Zabirova AH — data analysis; all authors — data interpretation; Suponeva NA, Bakulin IS, Poydasheva AG — manuscript draft writing; all authors — manuscript editing.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Center of Neurology (protocol 3-7/22 dated 20 April 2022), it was conducted in accordance with the principles of the Declaration of Helsinki; the informed consent was submitted by all study participants.

Received: 2023-10-07 Accepted: 2023-11-13 Published online: 2023-12-07
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Fig. Individual comodulogram of healthy volunteer. The color scale indicates the values of mean vector length (MVL); maximum theta–gamma coupling is marked with the red circle (frequencies of 7,6; 40 Hz)
Table 1. Individual theta–gamma coupling frequencies
Table 2. Adverse events during stimulation and within 24 h after stimulation
Note: iTBS-5/50 — standard theta-burst stimulation protocol, iTBS-ind — personalized theta-burst stimulation protocol, iTBS-sham — sham stimulation
Table 3. Effects of distinct protocols on the results of cognitive tests
Note: iTBS-5/50 — standard theta-burst stimulation protocol, iTBS-ind — personalized iTBS protocol, iTBS-sham — sham stimulation; Т1-Т0 — difference between values measured immediately after and before stimulation (hereinafter the data are presented as М [Q1; Q3]), Т2-Т0 — difference between values measured 60 min after the end of stimulation and before stimulation; L — verbal stimuli, S — spatial stimuli, Total — total d’ value for verbal and spatial stimuli with the same n; Digit Span — test for assessment of the sequence of digits recall, Corsi blocks — test for assessment of the spatial sequence recall; Tower of London — Tower of London test; significant differences (p < 0.05, pairwise comparison using the Bonferroni adjusted Wilcoxon test) are marked in bold; positive difference values correspond to performance improvement in all tests, except Tower of London
Table 4. Comparison of effects between protocols
Note: pT1-T0 — significance level for differences of values measured at Т1 and Т0, pT2-T0 and pT2-T1 — the same for Т2 and Т0, Т2 and Т1, respectively; L — verbal stimuli, S — spatial stimuli, Total — total d’ value for verbal and spatial stimuli with the same n; Digit Span — test for assessment of the sequence of digits recall, Corsi blocks — test for assessment of the spatial sequence recall; Tower of London — Tower of London test; significant differences are marked in bold (p < 0.05, comparison using the Friedman test)
Table 5. Pairwise comparison of the effects of protocols
Note: Identification of protocols: iTBS-5/50 — standard theta-burst stimulation protocol, iTBS-ind — personalized iTBS protocol, iTBS-sham — sham stimulation; pT2-T0 — significance level for differences of values measured at Т2 and Т0, pT2-T1 — significance level for differences of values measured at Т2 and Т1; S — spatial stimuli, Corsi blocks — test for assessment of the spatial sequence recall; significant differences are marked in bold (p < 0.05, Wilcoxon test adjusted for multiple comparisons)