ISSN Print 2500–1094
ISSN Online 2542–1204
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
Copyright: © 2026 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).
ORIGINAL RESEARCH
Experimental investigation of the burn-healing properties of a novel cream based on polyprenols derived from Ginkgo biloba L.
About authors
1 Medical Institute, Turgenev Orel State University, Orel, Russia
2 All-Union Scientific Center for the Safety of Biologically Active Substances, Staraya Kupavna, Moscow region, Russia
3 Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia
4 Pirogov Russian National Research Medical University, Moscow, Russia
Correspondence should be addressed: Alexandra A. Bobrakova
Komsomolskaya, 95, 302026, Orel, Russia; ur.liam@2102ardnaxelavokivon
About paper
Author contribution: Bobrakova AA, Salikhova NG — concept development; Panteleeva AN, Bobrakova AA — conducting the study; Bobrakova AA, Proskurina OV — text preparation and editing; Yasnetsov VV, Balabanyan VYu — approval of the final version of the article.
Compliance with ethical standards: the study was approved by the Ethics Committee of All-Union Scientific Center for the Safety of Biologically Active Substances (Minutes No. 05/2025 of April 30, 2025), conducted in accordance with GOST 33044-2014 "Principles of good laboratory practice", Decision of the Council of the Eurasian Economic Commission of November 3, 2016 No. 81 "On approval of the rules of good laboratory practice of the Eurasian Economic Union in the field of drug circulation," and Recommendations of the Board of the Eurasian Economic Commission of November 14, 2023 No. 33 "Guidelines for working with laboratory (experimental) animals during preclinical (non-clinical) studies."
Received: 2026-05-12
Accepted: 2026-05-28
Published online: 2026-06-18
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Fig. 1. The effect of the new polyprenol cream versus methyluracil and dexpanthenol ointments on skin lesion area dynamics in rats with grade III-B thermal burns (mean ± SE). The damaged skin area on day 1 after the burn was taken as baseline (100%). Here and in Figures 2 and 3: C — control; M — methyluracil; D — dexpanthenol; PP — the new polyprenol-based cream. Significance of differences with the control: * — p < 0.05 (Student's t-test)
Fig. 2. Morphological changes in the skin of rats, day 21 after burn (hematoxylin and eosin staining; 10 × 4)
Fig. 3. The effect of the new polyprenol cream versus methyluracil and dexpanthenol ointments on the degree of histological changes in the skin (points, M ± m) of rats with grade III-B thermal burns. The differences are significant compared to the control and methyluracil, respectively: * and ° — p < 0.05 (Student's t-test)
