2026 / 03

DOI: 10.24075/brsmu.2026.032
Copyright: © 2026 by the authors. Licensee: Pirogov University.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (CC BY).

ORIGINAL RESEARCH

Experimental investigation of the burn-healing properties of a novel cream based on polyprenols derived from Ginkgo biloba L.

Bobrakova AA1 , Salikhova NG2 , Panteleeva AN2 , Yasnetsov VV2,3 , Proskurina OV2 , Balabanyan VYu4
About authors

1 Medical Institute, Turgenev Orel State University, Orel, Russia

2 All-Union Scientific Center for the Safety of Biologically Active Substances, Staraya Kupavna, Moscow region, Russia

3 Institute for Biomedical Problems of the Russian Academy of Sciences, Moscow, Russia

4 Pirogov Russian National Research Medical University, Moscow, Russia

Correspondence should be addressed: Alexandra A. Bobrakova
Komsomolskaya, 95, 302026, Orel, Russia; ur.liam@2102ardnaxelavokivon

About paper

Author contribution: Bobrakova AA, Salikhova NG — concept development; Panteleeva AN, Bobrakova AA — conducting the study; Bobrakova AA, Proskurina OV — text preparation and editing; Yasnetsov VV, Balabanyan VYu — approval of the final version of the article.

Compliance with ethical standards: the study was approved by the Ethics Committee of All-Union Scientific Center for the Safety of Biologically Active Substances (Minutes No. 05/2025 of April 30, 2025), conducted in accordance with GOST 33044-2014 "Principles of good laboratory practice", Decision of the Council of the Eurasian Economic Commission of November 3, 2016 No. 81 "On approval of the rules of good laboratory practice of the Eurasian Economic Union in the field of drug circulation," and Recommendations of the Board of the Eurasian Economic Commission of November 14, 2023 No. 33 "Guidelines for working with laboratory (experimental) animals during preclinical (non-clinical) studies."

Received: 2026-05-12 Accepted: 2026-05-28 Published online: 2026-06-18
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  1. Sultanova KT, Kryshen KL, Borovkova KE, i dr. Patogenez inficirovannoj ozhogovoj rany u krys. Laboratornye zhivotnye dlya nauchnyh issledovanij. 2023; 2: 35–42. Russian.
  2. Mihalevich EN, Koval'skaya G. N. Obzor sovremennyh lekarstvennyh sredstv dlya naruzhnogo primeneniya, ispol'zuemyh v farmakoterapii ozhogovoj travmy. Voprosy obespecheniya kachestva lekarstvennyh sredstv. 2024; 1: 97–105. Russian.
  3. Palmieri TL, Heard J. Biomarkers of sepsis in burn injury: an update. Burns Trauma. 2025; 13: tkae080.
  4. Samojlova AV, Gostyuhina AA, Bolshakov MA, Rostov VV. Effekt stimulyacii zazhivleniya ozhogovyh ran u krys nanosekundnymi mikrovolnovymi impul'sami. Sovremennye voprosy biomediciny. 2022; 6 (1). DOI: 10.51871/2588-0500_2022_06_01_8. Russian.
  5. Kochneva EV, Maharoblishvili DV, Kolcova YuE. Znachenie poliprenolov v klinicheskoj i eksperimental'noj praktike. Voprosy dietologii. 2020; 10 (2): 35–43. Russian.
  6. Shustov EB, Kashuro VA, Batocyrenova EG. i dr. Poliprenoly kak perspektivnye nejrofarmakologicheskie sredstva. Biomedicina. 2020; 16 (3): 125–9. Russian.
  7. Antipina AA, Popov VS, Balaban'yan VYu. Poliprenoly kak original'nyj klass prirodnyh soedinenij, obladayushchih shirokim spektrom farmakologicheskoj aktivnosti. Farmaciya. 2021; 70 (5): 15–21. Russian.
  8. Sanin AV, Pronin AV, Narovlyanskij AN, i dr. Fosforilirovannye poliprenoly kak universal'nye agenty podavleniya virusnoj reprodukcii. Uspekhi sovremennoj biologii. 2022; 142 (3): 268–85. Russian.
  9. Boateng ID. Polyprenols in Ginkgo biloba; a review of their chemistry (synthesis of polyprenols and their derivatives), extraction, purification, and bioactivities. Food Chem. 2023; 418: 136006.
  10. Antipina AA, Popov NS, Baranov MS, i dr. Sravnitel'naya harakteristika kolichestvennogo soderzhaniya poliprenolov v substanciyah, poluchennyh iz Ginkgo biloba L. i Picea abies L. Voprosy biologicheskoj, medicinskoj i farmacevticheskoj himii. 2024; 27 (8): 13–21. Russian.
  11. Buryakina AV, Frolova NYu, Melnikova TI, i dr. Metodicheskie rekomendacii po doklinicheskomu izucheniyu dermatotropnyh lekarstvennyh sredstv. Rukovodstvo po provedeniyu doklinicheskih issledovanij lekarstvennyh sredstv. Ch. 1. M., 2012: 738–45. Russian.
  12. Vajs EV, Tursunova NV, Hushbaktova ZA, Syrov VN. Ob effektivnosti poliprenolov iz Alceae Nudiflora pri ispol'zovanii ih v kachestve protivoozhogovogo sredstva. Prakticheskaya fitoterapiya. 2011; 2: 12–16. Russian.
  13. Vajs EV, Tursunova NV, Hushbaktova ZA, Syrov VN. Vliyanie poliprenolov iz Alceae nudiflora i oblepihovogo masla na metabolizm kozhi i process zazhivleniya linejnyh kozhnyh ran u normal'nyh i alloksan-diabeticheskih krys. Infekciya, immunitet i farmakologiya. Tashkent. 2012; 2: 25–28. Russian.
  14. Yusupova SM, Vajs EV, Zokirova UT, i dr. Poliprenoly list'ev Vitis Vinifera S.: vydelenie i izuchenie ranozazhivlyayushchej aktivnosti. ZHurnal teoreticheskoj i klinicheskoj mediciny. 2019; 4: 26–28. Russian.
  15. Lacerus LA. Primenenie terpenoidsoderzhashchego preparata abisil v lechenii i profilaktike hirurgicheskoj infekcii. Rossijskij bioterapevticheskij zhurnal. 2010; 9 (1): 39–41. Russian.
  16. Tursunova NV, Klinnikova MG, Tornuev YuV, Lushnikova EL. Rastitel'nye poliprenoly kak perspektivnyj klass soedinenij, stimuliruyushchih regeneratornye processy. Sovremennye problemy nauki i obrazovaniya. 2019; 4. URL: https://science-education.ru/ru/article/view?id=28977 (data obrashcheniya: 19.05.2026). Russian.
  17. Cavallini G, Sgarbossa A, Parentini I, et al. Dolichol: A component of the cellular antioxidant machinery. Lipids. 2016; 51 (4): 477–86.
  18. Ciepichal E, Jemiola-Rzeminska M, Hertel J, et al. Configuration of polyisoprenoids affects the permeability and thermotropic properties of phospholipid/polyisoprenoid model membranes. Chem Phys Lipids. 2011; 164 (4): 300–6.
  19. Lebedeva SA, Galenko-YAroshevskij (ml.) PA, Melnik SI, i dr. Ranozazhivlyayushchee dejstvie metalloorganicheskogo kompleksa cinka na modeli ploskostnoj kozhnoj rany u krys. Nauchnye rezul'taty biomedicinskih issledovanij. 2022; 8 (1): 71– 81. Russian.
  20. Fokina NA, Uryadova GT, Tyapkin AYu, i dr. Dejstvie ekzopolisaharidov molochnokislyh bakterij na process zazhivleniya ozhogov u krys. Ul'yanovskij mediko-biologicheskij zhurnal. 2018; 4: 117–23. Russian.
  21. Zinchenko IA, Struc IS, Mironcev AV, i dr. Izuchenie ranozazhivlyayushchego dejstviya nanochastic serebra i ceriya pri lechenii neoslozhnennyh kozhnyh ran v eksperimente. Operativnaya hirurgiya i klinicheskaya anatomiya (Pirogovskij nauchnyj zhurnal). 2024; 8 (4): 18–24. Russian.