ISSN Print 2500–1094
ISSN Online 2542–1204
Bulletin of RSMU
BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)
ORIGINAL RESEARCH
Genetic polymorphism of Staphylococcus epidermidis strains in patients of the Neonatal Intensive Care Unit
About authors
1 Department of Microbiology and Clinical Pharmacology,
Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
2 Department of Clinical and Molecular Genetics,
Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
3 Department of Neonatology and Pediatrics,
Kulakov Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia
Correspondence should be addressed: Alexey B. Gordeev
ul. Akademika Oparina, d. 4, Moscow, Russia, 117997; ur.sertorp.agev@weedrog
About paper
Funding: this study was supported by the Grant Agreement No. 14.607.21.0019 of the Ministry of Science and Education of the Russian Federation
dated June 5, 2014 (ID 2014-14-579-0001-065).
Contribution of the authors to this work: Gordeev AB — bioinformatics analysis of nucleotide sequences, analysis of literature, drafting of a manuscript; Lyubasovskaya LA — micribiological studies, analysis of literature, data interpretation, drafting of a manuscript; Rodchenko JV, Dubodelov DV — microbiological studies, drafting of a manuscript; Mukosey IS, Kochetkova TO — whole genome suquencing and genome assembling; Nikitina IV — research planning, data interpretation; Ionov OB, Zubkov VV — research planning, organization of biomaterial sampling; Trofimov DYu — research planning, organization of whole genome sequencing; Priputnevich TV — research planning, organization of microbiological studies, data interpretation, drafting of a manuscript. All authors participated in editing of the manuscript.
Received: 2017-02-02
Accepted: 2017-02-18
Published online: 2017-03-11
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Table 1. Genome assembly o S. epidermidis strains based on whole-genome sequencing data
Table 2. Antibiotic resistance of S. epidermidis strains
Note. R — resistant strain, S — sensitive strain.
Table 3. Resistance genes in S. epidermidis
Note. Symbols + and – represent the presence and absence of the resistance gene in the strain genome. Gene aacA-aphD mediates resistance to amikacin, gentamycin, kanamycin, and tobramycin; gene aadD mediates resistance to amikacin, kanamycin, neomycin and tobramycinl; aphA mediates resistance to kanamycin and neomycin; blaZ — to penicillins; mecA — to beta-lactam antibiotics; fusB and fusC to fusidic acid; vanA, vanB, and vanZ to vancamycin; lnu(A), vga(A), and vga(B) — to licosamides (clindamycin); msr(A) and mph(C) — to macrolide antibiotics (erythromycin); erm(A), erm(B), and erm(C) — to macrolide antibiotics and lincosamides; vat(B) — to streptogramin B; tet(M) and tet(K) — to tetracycline; dfr(G) and dfr(K) — to trimethoprim.
Table 4. Genes associated with virulence in S. epidermidis
Note. Symbols + and – represent the presence and absence of a resistance gene in the strain genome.
