Bulletin of RSMU

ISSN Print 2500–1094 ISSN Online 2542–1204

Bulletin of RSMU

BIOMEDICAL JOURNAL OF PIROGOV UNIVERSITY (MOSCOW, RUSSIA)

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Volkova EV, Lysyuk EYu, Djokhadze LS, Makarov OV

The aim of our study was to examine changes in levels of vascular growth factors in pregnant women with chronic hypertension (CH). There was carried out a clinical analysis of pregnancy, childbirth, postpartum and postnatal outcomes in 69 pregnant women with CH and 49 women with physiological course of pregnancy. The levels of proangiogenic (PlGF) and antiangiogenic (sFlt-1, sEng) factors in the serum of 28–34 weeks' gestation were investigated in all pregnant women with immune-enzyme analysis. At pregnancy with the CH there was observed an increase in the concentration of antiangiogenic proteins sFlt-1 to 5573 ± 774 pg/ml (3299 ± 544 pg/ml in control, p < 0.05) and endoglin to 7.1 ± 0.8 ng/ml (control 5.4 ± 0.4 ng/ml, p < 0.05). At the same time there was a decrease of proangiogenic PlGF (155.8 ± 30.4 pg/ml vs 238.5 ± 66.1 pg/ml in controls, p < 0.05).

Received: 2012-03-27

Published online: 2017-01-05

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VIEWS 3746

Skoroglyadov AV, Naumenko MV, Zinchenko AV, Korobushkin GV

The paper presents a review of literature and the stored experience of the Department of traumatology, orthopedics and battle-field surgery of RNRMU named after N. I. Pirogov in diagnostics and treatment of osteochondral fractures of the talus as one of the main reasons for chronic pain in an ankle joint in people of efficient age.

Received: 2012-04-09

Published online: 2017-01-05

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VIEWS 3881

The aim of this research is the rationalization of the innovation system-factor of modern university education. The analysis of the present situation in university's education was conducted in terms of trends in the continuum of individualism-corporatism. A trend to the atomization of interests was shown as the main motivational factors of modern education, the entropic dynamic character of resource development was shown, the lack of their consolidating component. The characteristics of the necessary system-factor were given.

Received: 2011-12-19

Published online: 2017-01-05

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VIEWS 3838

Askanidi IP, Pyshkina LI, Serguladze TN

The article contains modern data review of a brain perfusion on extra- and intracranial levels during occlusion diseases of brachiocephalic arteries. In patients with brain ischemia there were described the possibilities of assessing the level of perfusion by noninvasive methods: single-proton emission computed tomography with <sup>99m</sup>Tc-HMPAO and ultrasound diagnostic methods with functional loading tests.

Received: 2012-04-18

Published online: 2017-01-05

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VIEWS 3869

Panova OV, Stakhanov VA, Stenina MA, Voevodin DA, Krivov LI

The aim of the study was to evaluate the clinical features of the course of tuberculosis in infants and preschool children against herpes infection. The presence of viral infection was noted on detection of DNA viruses: the Epstein-Barr virus, herpes simplex virus type VI, cytomegalovirus in blood mononuclear cells of children. According to the results of PCR diagnosis, 28 (the 1st group) of the 61 children surveyed were infected with herpes viruses, 33 children (the 2nd group) — were not infected with those viruses. The frequency of comorbidity was higher in the 1st group. 12 of 14 children diagnosed with tuberculosis intoxication were infected with herpes viruses. Tuberculosis intoxication in the structure of the clinical forms of tuberculosis in the 1st group was 43 %, and in the 2nd group was only 6 %. The role of viral suppression of dendritic cells as a possible factor in the suppression of specific immune response to Mycobacterium tuberculosis in the mediastinal lymph nodes and the emergence of "minor" forms of tuberculosis in children was discussed.

Received: 2012-04-18

Published online: 2017-01-05

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VIEWS 3921

Nazarenko GI, Darenkov SP, Zyryanova ON, Sakrisyan AD

The article is devoted to modern techniques of surgical treatment of Peyronie's disease. To date, surgery is the main effective means of therapy of this symptomatic disease. There is proposed a set of techniques that can be divided into two groups of operations: shortening (Nesbit operation and its modifications, plication) and lengthening (patchwork) corporoplasty. Shortening techniques proved to be effective, and subjected to certain indications for their use, are considered satisfactory by professionals and patients. Among them the most preferred are modified Nesbit operations. When prolonging corporoplasty today probably there is no need for complete excision of the plaque, and the most contentious issue is the selection of optimal plastic automaterial. The author presented a case of his own experience of surgical treatment of Peyronie's disease symptom.

Received: 2012-04-04

Published online: 2017-01-05

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VIEWS 4013

Kovalchuk LV, Gankovskaya LV, Rakhmanova IV, Svitich OA, Zinker GM, Gankovskiy VA, Kartashov DD, Volkova YuV, Russanova KV

The results of the study of the effectiveness of personalized immunotherapy in children with hypertrophy of II–III degree adenoid vegetations are presented in the article. It was established, that application of autologous complex of immunopeptides including cytokines and antimicrobial peptides produced by white blood cells of the patients, led to the normalization of nasal breathing, a reduction in the frequency of otitis and of respiratory viral infections at 6 months observation after the treatment. There were identified individual differences in gene expression of molecules of the innate immunity in the mucosa of the nasal cavity, what provides the personalized approach to immunotherapy.

Received: 2012-04-17

Published online: 2017-01-05

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VIEWS 4116

Mikhaylova SD, Semushkina TM, Sokolov AV, Mikaelyan NP, Storozhakov GI

In the acute experiments on rabbits there was discovered an impulse activity of afferent and interneurons of the medullar cardiovascular center in the conditions of hypoxia and hypercapnia. Afferent neurons received information on myelinated fibers of vagus nerve and caused reaction on hypercapnia in one per three cases. Interneurons received information simultaneously on both myelinated and unmyelinated fibers of vagus nerves. They reacted both on hypoxia and hypercapnia.

Received: 2012-01-30

Published online: 2017-01-05

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VIEWS 3968